| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | De novo enzymes by computational design |
| Autor/-in: | Kries, Hajo Blomberg, Rebecca Hilvert, Donald |
| DOI: | 10.1016/j.cbpa.2013.02.012 |
| Erschienen in: | Current Opinion in Chemical Biology |
| Band(Heft): | 17 |
| Heft: | 2 |
| Seite(n): | 221 |
| Seiten bis: | 228 |
| Erscheinungsdatum: | 2013 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 1367-5931 1879-0402 |
| Sprache: | Englisch |
| Schlagwörter: | Algorithms; Computational biology; Directed molecular evolution; Enzymes; Protein engineering |
| Fachgebiet (DDC): | 004: Informatik 660.6: Biotechnologie |
| Zusammenfassung: | Computational enzyme design has emerged as a promising tool for generating made-to-order biocatalysts. In addition to improving the reliability of the design cycle, current efforts in this area are focusing on expanding the set of catalyzed reactions and investigating the structure and mechanism of individual designs. Although the activities of de novo enzymes are typically low, they can be significantly increased by directed evolution. Analysis of their evolutionary trajectories provides valuable feedback for the design algorithms and can enhance our understanding of natural protein evolution. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/9662 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Kries, H., Blomberg, R., & Hilvert, D. (2013). De novo enzymes by computational design. Current Opinion in Chemical Biology, 17(2), 221–228. https://doi.org/10.1016/j.cbpa.2013.02.012
Kries, H., Blomberg, R. and Hilvert, D. (2013) ‘De novo enzymes by computational design’, Current Opinion in Chemical Biology, 17(2), pp. 221–228. Available at: https://doi.org/10.1016/j.cbpa.2013.02.012.
H. Kries, R. Blomberg, and D. Hilvert, “De novo enzymes by computational design,” Current Opinion in Chemical Biology, vol. 17, no. 2, pp. 221–228, 2013, doi: 10.1016/j.cbpa.2013.02.012.
KRIES, Hajo, Rebecca BLOMBERG und Donald HILVERT, 2013. De novo enzymes by computational design. Current Opinion in Chemical Biology. 2013. Bd. 17, Nr. 2, S. 221–228. DOI 10.1016/j.cbpa.2013.02.012
Kries, Hajo, Rebecca Blomberg, and Donald Hilvert. 2013. “De Novo Enzymes by Computational Design.” Current Opinion in Chemical Biology 17 (2): 221–28. https://doi.org/10.1016/j.cbpa.2013.02.012.
Kries, Hajo, et al. “De Novo Enzymes by Computational Design.” Current Opinion in Chemical Biology, vol. 17, no. 2, 2013, pp. 221–28, https://doi.org/10.1016/j.cbpa.2013.02.012.
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