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Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
Art der Begutachtung: Keine Angabe
Titel: Natural selection at coding and non-coding DNA mainly affects pathogenicity-related genes in the hemibiotrophic fungus Colletotrichum graminicola
Autor/-in: Rech, Gabriel E.
Sanz-Martín, José M.
Anisimova, Maria
Sukno, Serenella A.
Thon, Michael R.
DOI: 10.21256/zhaw-3888
10.1093/gbe/evu192
Erschienen in: Genome Biology and Evolution
Band(Heft): 6
Heft: 9
Seite(n): 2368
Seiten bis: 2379
Erscheinungsdatum: 2014
Verlag / Hrsg. Institution: Oxford University Press
ISSN: 1759-6653
Sprache: Englisch
Schlagwörter: Positive selection; PAML; Colletotrichum graminicola; Pathogenicity; Arms race hypothesis
Fachgebiet (DDC): 570: Biologie
572: Biochemie
Zusammenfassung: Natural selection leaves imprints on DNA, offering the opportunity to identify functionally important regions of the genome. Identifying the genomic regions affected by natural selection within pathogens can aid in the pursuit of effective strategies to control diseases. In this study, we analyzed genome-wide patterns of selection acting on different classes of sequences in a worldwide sample of eight strains of the model plant-pathogenic fungus Colletotrichum graminicola. We found evidence of selective sweeps, balancing selection, and positive selection affecting both protein-coding and noncoding DNA of pathogenicity-related sequences. Genes encoding putative effector proteins and secondary metabolite biosynthetic enzymes show evidence of positive selection acting on the coding sequence, consistent with an Arms Race model of evolution. The 5′ untranslated regions (UTRs) of genes coding for effector proteins and genes upregulated during infection show an excess of high-frequency polymorphisms likely the consequence of balancing selection and consistent with the Red Queen hypothesis of evolution acting on these putative regulatory sequences. Based on the findings of this work, we propose that even though adaptive substitutions on coding sequences are important for proteins that interact directly with the host, polymorphisms in the regulatory sequences may confer flexibility of gene expression in the virulence processes of this important plant pathogen.
URI: https://digitalcollection.zhaw.ch/handle/11475/8275
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): CC BY 4.0: Namensnennung 4.0 International
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Computational Life Sciences (ICLS)
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

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