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Title: Darwin and Fisher meet at biotech : on the potential of computational molecular evolution in industry
Authors : Anisimova, Maria
Published in : BMC Evolutionary Biology
Volume(Issue) : 15
Pages : 76
Pages to: 85
Publisher / Ed. Institution : BioMed Central
Issue Date: 2015
License (according to publishing contract) : CC BY 4.0: Namensnennung 4.0 International
Type of review: Peer review (Publication)
Language : English
Subjects : Animal; Biotechnology; Computational biology; Human; Metabolome; Proteins; Genetic selection; Molecular evolution; Genomics
Subject (DDC) : 570: Biology
660.6: Biotechnology
Abstract: Today computational molecular evolution is a vibrant research field that benefits from the availability of large and complex new generation sequencing data - ranging from full genomes and proteomes to microbiomes, metabolomes and epigenomes. The grounds for this progress were established long before the discovery of the DNA structure. Specifically, Darwin's theory of evolution by means of natural selection not only remains relevant today, but also provides a solid basis for computational research with a variety of applications. But a long-term progress in biology was ensured by the mathematical sciences, as exemplified by Sir R. Fisher in early 20th century. Now this is true more than ever: The data size and its complexity require biologists to work in close collaboration with experts in computational sciences, modeling and statistics.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Applied Simulation (IAS)
Publication type: Article in scientific Journal
DOI : 10.1186/s12862-015-0352-y
ISSN: 1471-2148
Appears in Collections:Publikationen Life Sciences und Facility Management

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