| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium |
| Autor/-in: | Garcia, Victor Glassberg, Emily C. Harpak, Arbel Feldman, Marcus W. |
| DOI: | 10.1098/rsif.2017.0921 |
| Erschienen in: | Journal of the Royal Society Interface |
| Band(Heft): | 15 |
| Heft: | 140 |
| Erscheinungsdatum: | 21-Mär-2018 |
| Verlag / Hrsg. Institution: | The Royal Society |
| ISSN: | 1742-5689 1742-5662 |
| Sprache: | Englisch |
| Schlagwörter: | Genetic interference; Human immunodeficiency virus; Multilocus linkage disequilibrium |
| Fachgebiet (DDC): | 572: Biochemie 616: Innere Medizin und Krankheiten |
| Zusammenfassung: | Within-host adaptation of pathogens such as human immunodeficiency virus (HIV) often occurs at more than two loci. Multiple beneficial mutations may arise simultaneously on different genetic backgrounds and interfere, affecting each other's fixation trajectories. Here, we explore how these evolutionary dynamics are mirrored in multilocus linkage disequilibrium (MLD), a measure of multi-way associations between alleles. In the parameter regime corresponding to HIV, we show that deterministic early infection models induce MLD to oscillate over time in a wavelet-like fashion. We find that the frequency of these oscillations is proportional to the rate of adaptation. This signature is robust to drift, but can be eroded by high variation in fitness effects of beneficial mutations. Our findings suggest that MLD oscillations could be used as a signature of interference among multiple equally advantageous mutations and may aid the interpretation of MLD in data. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/7498 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Computational Life Sciences (ICLS) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Garcia, V., Glassberg, E. C., Harpak, A., & Feldman, M. W. (2018). Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium. Journal of the Royal Society Interface, 15(140). https://doi.org/10.1098/rsif.2017.0921
Garcia, V. et al. (2018) ‘Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium’, Journal of the Royal Society Interface, 15(140). Available at: https://doi.org/10.1098/rsif.2017.0921.
V. Garcia, E. C. Glassberg, A. Harpak, and M. W. Feldman, “Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium,” Journal of the Royal Society Interface, vol. 15, no. 140, Mar. 2018, doi: 10.1098/rsif.2017.0921.
GARCIA, Victor, Emily C. GLASSBERG, Arbel HARPAK und Marcus W. FELDMAN, 2018. Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium. Journal of the Royal Society Interface. 21 März 2018. Bd. 15, Nr. 140. DOI 10.1098/rsif.2017.0921
Garcia, Victor, Emily C. Glassberg, Arbel Harpak, and Marcus W. Feldman. 2018. “Clonal Interference Can Cause Wavelet-like Oscillations of Multilocus Linkage Disequilibrium.” Journal of the Royal Society Interface 15 (140). https://doi.org/10.1098/rsif.2017.0921.
Garcia, Victor, et al. “Clonal Interference Can Cause Wavelet-like Oscillations of Multilocus Linkage Disequilibrium.” Journal of the Royal Society Interface, vol. 15, no. 140, Mar. 2018, https://doi.org/10.1098/rsif.2017.0921.
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