Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
Art der Begutachtung: | Peer review (Publikation) |
Titel: | A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes |
Autor/-in: | Rohrer, Jack Schweizer, Anja Johnson, Karl F. Kornfeld, Stuart |
DOI: | 10.1083/jcb.130.6.1297 |
Erschienen in: | Journal of Cell Biology |
Band(Heft): | 130 |
Heft: | 6 |
Seite(n): | 1297 |
Seiten bis: | 1306 |
Erscheinungsdatum: | 15-Sep-1995 |
Verlag / Hrsg. Institution: | Rockefeller University Press |
ISSN: | 0021-9525 |
Sprache: | Englisch |
Fachgebiet (DDC): | 572: Biochemie |
Zusammenfassung: | The bovine cation-dependent mannose 6-phosphate receptor (CD-MPR) is a type 1 transmembrane protein that cycles between the trans-Golgi network, endosomes, and the plasma membrane. When the terminal 40 residues were deleted from the 67-amino acid cytoplasmic tail of the CD-MPR, the half-life of the receptor was drastically decreased and the mutant receptor was recovered in lysosomes. Analysis of additional cytoplasmic tail truncation mutants and alanine-scanning mutants implicated amino acids 34-39 as being critical for avoidance of lysosomal degradation. The cytoplasmic tail of the CD-MPR was partially effective in preventing the lysosomal membrane protein Lamp1 from entering lysosomes. Complete exclusion required both the CD-MPR cytoplasmic tail and transmembrane domain. The transmembrane domain alone had just a minor effect on the distribution of Lamp1. These findings indicate that the cytoplasmic tail of the CD-MPR contains a signal that prevents the receptor from trafficking to lysosomes. The transmembrane domain of the CD-MPR also contributes to this function. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/6831 |
Volltext Version: | Publizierte Version |
Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
Departement: | Life Sciences und Facility Management |
Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.
Zur Langanzeige
Rohrer, J., Schweizer, A., Johnson, K. F., & Kornfeld, S. (1995). A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes. Journal of Cell Biology, 130(6), 1297–1306. https://doi.org/10.1083/jcb.130.6.1297
Rohrer, J. et al. (1995) ‘A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes’, Journal of Cell Biology, 130(6), pp. 1297–1306. Available at: https://doi.org/10.1083/jcb.130.6.1297.
J. Rohrer, A. Schweizer, K. F. Johnson, and S. Kornfeld, “A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes,” Journal of Cell Biology, vol. 130, no. 6, pp. 1297–1306, Sep. 1995, doi: 10.1083/jcb.130.6.1297.
ROHRER, Jack, Anja SCHWEIZER, Karl F. JOHNSON und Stuart KORNFELD, 1995. A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes. Journal of Cell Biology. 15 September 1995. Bd. 130, Nr. 6, S. 1297–1306. DOI 10.1083/jcb.130.6.1297
Rohrer, Jack, Anja Schweizer, Karl F. Johnson, and Stuart Kornfeld. 1995. “A Determinant in the Cytoplasmic Tail of the Cation-Dependent Mannose 6-Phosphate Receptor Prevents Trafficking to Lysosomes.” Journal of Cell Biology 130 (6): 1297–1306. https://doi.org/10.1083/jcb.130.6.1297.
Rohrer, Jack, et al. “A Determinant in the Cytoplasmic Tail of the Cation-Dependent Mannose 6-Phosphate Receptor Prevents Trafficking to Lysosomes.” Journal of Cell Biology, vol. 130, no. 6, Sept. 1995, pp. 1297–306, https://doi.org/10.1083/jcb.130.6.1297.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.