| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family |
| Autor/-in: | Schweizer, Anja Valdenaire, Olivier Köster, Anja Lang, Yolande Schmitt, Georg Lenz, Barbara Bluethmann, Horst Rohrer, Jack |
| DOI: | 10.1074/jbc.274.29.20450 |
| Erschienen in: | Journal of Biological Chemistry |
| Band(Heft): | 274 |
| Heft: | 29 |
| Seite(n): | 20450 |
| Seiten bis: | 20456 |
| Erscheinungsdatum: | 16-Jul-1999 |
| Verlag / Hrsg. Institution: | American Society for Biochemistry and Molecular Biology |
| ISSN: | 1083-351X |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in specific areas of the central nervous system including spinal chord and medulla. To elucidate the importance and function of XCE, we disrupted its gene in mouse embryonic stem cells by homologous recombination and created mice deficient in XCE. The resulting phenotype is characterized by neonatal lethality. All XCE -/- homozygous mice died of respiratory failure shortly after birth, and in most cases their lungs were never ventilated. Apart from the atelectasis, anatomical and histological examinations of embryonic day 18.5 XCE -/- embryos and newborn homozygotes did not reveal any obvious abnormalities in organs and tissues. Malformations that are related to the knock-out were also not found in the skeletons of XCE -/- mice. In addition, XCE knock-out animals showed no deficiency of pulmonary surfactant proteins and had normal heart beat frequencies. Taken together, our results demonstrate that XCE is an essential gene. The phenotype of the XCE-deficient mice together with the central nervous system-specific expression further suggest that XCE may play a vital role in the control of respiration. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/6804 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Schweizer, A., Valdenaire, O., Köster, A., Lang, Y., Schmitt, G., Lenz, B., Bluethmann, H., & Rohrer, J. (1999). Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family. Journal of Biological Chemistry, 274(29), 20450–20456. https://doi.org/10.1074/jbc.274.29.20450
Schweizer, A. et al. (1999) ‘Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family’, Journal of Biological Chemistry, 274(29), pp. 20450–20456. Available at: https://doi.org/10.1074/jbc.274.29.20450.
A. Schweizer et al., “Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family,” Journal of Biological Chemistry, vol. 274, no. 29, pp. 20450–20456, Jul. 1999, doi: 10.1074/jbc.274.29.20450.
SCHWEIZER, Anja, Olivier VALDENAIRE, Anja KÖSTER, Yolande LANG, Georg SCHMITT, Barbara LENZ, Horst BLUETHMANN und Jack ROHRER, 1999. Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family. Journal of Biological Chemistry. 16 Juli 1999. Bd. 274, Nr. 29, S. 20450–20456. DOI 10.1074/jbc.274.29.20450
Schweizer, Anja, Olivier Valdenaire, Anja Köster, Yolande Lang, Georg Schmitt, Barbara Lenz, Horst Bluethmann, and Jack Rohrer. 1999. “Neonatal Lethality in Mice Deficient in XCE, a Novel Member of the Endothelin-Converting Enzyme and Neutral Endopeptidase Family.” Journal of Biological Chemistry 274 (29): 20450–56. https://doi.org/10.1074/jbc.274.29.20450.
Schweizer, Anja, et al. “Neonatal Lethality in Mice Deficient in XCE, a Novel Member of the Endothelin-Converting Enzyme and Neutral Endopeptidase Family.” Journal of Biological Chemistry, vol. 274, no. 29, July 1999, pp. 20450–56, https://doi.org/10.1074/jbc.274.29.20450.
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