Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3684
Title: Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate
Authors : Mazenauer, Manuel R.
Manov, Stole
Galati, Vanessa M.
Kappeler, Philipp
Stohner, Jürgen
Published in : RSC Advances
Volume(Issue) : 7
Issue : 87
Pages : 55434
Pages to: 55440
Publisher / Ed. Institution : Royal Society of Chemistry
Issue Date: 2017
License (according to publishing contract) : CC BY 3.0: Namensnennung 3.0 Unported
Type of review: Peer review (Publication)
Language : English
Subject (DDC) : 540: Chemistry
Abstract: Chiral halomethane is the smallest stable molecule with a single asymmetric C-atom and halogenated acetic acids often serve as precursors. We focus on a synthetic route to synthesise chiral halogenated acetic acids with F, Cl, Br, and H/D isotopic substitution at the α-C-atom starting from diethyl malonate. This reactant is easily available, cheap and allows the obtainment of target acids in a few reaction steps with great versatility. Among all of the possible fully halogenated acetic acids (more than one hundred, which are, in principle, accessible by this route), there are only a small number of chiral halogenated acetic acids, which have been synthesized following the devised synthetic route.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1039/C7RA09727A
10.21256/zhaw-3684
ISSN: 2046-2069
URI: https://digitalcollection.zhaw.ch/handle/11475/6407
Appears in Collections:Publikationen Life Sciences und Facility Management

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