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|Title:||Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate|
|Authors :||Mazenauer, Manuel R.|
Galati, Vanessa M.
|Published in :||RSC Advances|
|Publisher / Ed. Institution :||Royal Society of Chemistry|
|License (according to publishing contract) :||CC BY 3.0: Namensnennung 3.0 Unported|
|Type of review:||Peer review (Publication)|
|Subject (DDC) :||540: Chemistry|
|Abstract:||Chiral halomethane is the smallest stable molecule with a single asymmetric C-atom and halogenated acetic acids often serve as precursors. We focus on a synthetic route to synthesise chiral halogenated acetic acids with F, Cl, Br, and H/D isotopic substitution at the α-C-atom starting from diethyl malonate. This reactant is easily available, cheap and allows the obtainment of target acids in a few reaction steps with great versatility. Among all of the possible fully halogenated acetic acids (more than one hundred, which are, in principle, accessible by this route), there are only a small number of chiral halogenated acetic acids, which have been synthesized following the devised synthetic route.|
|Departement:||Life Sciences und Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Publication type:||Article in scientific Journal|
|Appears in Collections:||Publikationen Life Sciences und Facility Management|
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