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https://doi.org/10.21256/zhaw-1966| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy |
| Autor/-in: | Crameri, Aureliano von Wyl, Agnes Koemeda, Margit Schulthess, Peter Tschuschke, Volker |
| DOI: | 10.21256/zhaw-1966 10.3389/fpsyg.2015.01042 |
| Erschienen in: | Frontiers in Psychiatry |
| Band(Heft): | 6 |
| Erscheinungsdatum: | 27-Jul-2015 |
| Verlag / Hrsg. Institution: | Frontiers Research Foundation |
| ISSN: | 1664-0640 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 616.89: Psychische Störungen, klinische Psychologie und Psychiatrie |
| Zusammenfassung: | The importance of preventing and treating incomplete data in effectiveness studies is nowadays emphasized. However, most of the publications focus on randomized clinical trials (RCT). One flexible technique for statistical inference with missing data is multiple imputation (MI). Since methods such as MI rely on the assumption of missing data being at random (MAR), a sensitivity analysis for testing the robustness against departures from this assumption is required. In this paper we present a sensitivity analysis technique based on posterior predictive checking, which takes into consideration the concept of clinical significance used in the evaluation of intra-individual changes. We demonstrate the possibilities this technique can offer with the example of irregular longitudinal data collected with the Outcome Questionnaire-45 (OQ-45) and the Helping Alliance Questionnaire (HAQ) in a sample of 260 outpatients. The sensitivity analysis can be used to (1) quantify the degree of bias introduced by missing not at random data (MNAR) in a worst reasonable case scenario, (2) compare the performance of different analysis methods for dealing with missing data, or (3) detect the influence of possible violations to the model assumptions (e.g., lack of normality). Moreover, our analysis showed that ratings from the patient’s and therapist’s version of the HAQ could significantly improve the predictive value of the routine outcome monitoring based on the OQ-45. Since analysis dropouts always occur, repeated measurements with the OQ-45 and the HAQ analyzed with MI are useful to improve the accuracy of outcome estimates in quality assurance assessments and non-randomized effectiveness studies in the field of outpatient psychotherapy. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/5584 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Angewandte Psychologie |
| Organisationseinheit: | Psychologisches Institut (PI) |
| Publiziert im Rahmen des ZHAW-Projekts: | Praxisstudie ambulante Psychotherapie (PAP-S) |
| Enthalten in den Sammlungen: | Publikationen Angewandte Psychologie |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2015_Crameri_Sensitivity analysis.pdf | 741.92 kB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Crameri, A., von Wyl, A., Koemeda, M., Schulthess, P., & Tschuschke, V. (2015). Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy. Frontiers in Psychiatry, 6. https://doi.org/10.21256/zhaw-1966
Crameri, A. et al. (2015) ‘Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy’, Frontiers in Psychiatry, 6. Available at: https://doi.org/10.21256/zhaw-1966.
A. Crameri, A. von Wyl, M. Koemeda, P. Schulthess, and V. Tschuschke, “Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy,” Frontiers in Psychiatry, vol. 6, Jul. 2015, doi: 10.21256/zhaw-1966.
CRAMERI, Aureliano, Agnes VON WYL, Margit KOEMEDA, Peter SCHULTHESS und Volker TSCHUSCHKE, 2015. Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy. Frontiers in Psychiatry. 27 Juli 2015. Bd. 6. DOI 10.21256/zhaw-1966
Crameri, Aureliano, Agnes von Wyl, Margit Koemeda, Peter Schulthess, and Volker Tschuschke. 2015. “Sensitivity Analysis in Multiple Imputation in Effectiveness Studies of Psychotherapy.” Frontiers in Psychiatry 6 (July). https://doi.org/10.21256/zhaw-1966.
Crameri, Aureliano, et al. “Sensitivity Analysis in Multiple Imputation in Effectiveness Studies of Psychotherapy.” Frontiers in Psychiatry, vol. 6, July 2015, https://doi.org/10.21256/zhaw-1966.
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