Unambiguous identification of volatile organic compounds by proton-transfer-reaction mass-spectrometry (PTR-MS) coupled with GC-MS

Lindinger, Christian; Pollien, Philippe; Ali, Santo; Yeretzian, Chahan; Blank, Imre; Tilmann, Märk

doi:10.1021/ac0501240

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Unambiguous identification of volatile organic compounds by proton-transfer-reaction mass-spectrometry (PTR-MS) coupled with GC-MS
Authors:	Lindinger, Christian Pollien, Philippe Ali, Santo Yeretzian, Chahan Blank, Imre Tilmann, Märk
DOI:	10.1021/ac0501240
Published in:	Analytical Chemistry
Volume(Issue):	77
Issue:	13
Page(s):	4117
Pages to:	4124
Issue Date:	26-May-2005
Publisher / Ed. Institution:	American Chemical Society
Publisher / Ed. Institution:	Columbus
ISSN:	0003-2700 1520-6882
Language:	English
Subjects:	PTR-MS
Subject (DDC):	540: Chemistry
Abstract:	Interest in on-line measurements of volatile organic compounds (VOCs) is increasing, as sensitive, compact, and affordable direct inlet mass spectrometers are becoming available. Proton-transfer reaction mass spectrometry (PTR-MS) distinguishes itself by its high sensitivity (low ppt range), high time resolution (200 ms), little ionization-induced fragmentation, and ionization efficiency independent of the compound to be analyzed. Yet, PTR-MS has a shortcoming. It is a one-dimensional technique that characterizes compounds only via their mass, which is not sufficient for positive identification. Here, we introduce a technical and analytical extension of PTR-MS, which removes this shortcoming, while preserving its salient and unique features. Combining separation of VOCs by gas chromatography (GC) with simultaneous and parallel detection of the GC effluent by PTR-MS and electron impact MS, an unambiguous interpretation of complex PTR-MS spectra becomes feasible. This novel development is discussed on the basis of characteristic performance parameters, such as resolution, linear range, and detection limit. The recently developed drift tube with a reduced reaction volume is crucial to exploit the full potential of the setup. We illustrate the performance of the novel setup by analyzing a complex food system.
URI:	https://digitalcollection.zhaw.ch/handle/11475/5468
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Lindinger, C., Pollien, P., Ali, S., Yeretzian, C., Blank, I., & Tilmann, M. (2005). Unambiguous identification of volatile organic compounds by proton-transfer-reaction mass-spectrometry (PTR-MS) coupled with GC-MS. Analytical Chemistry, 77(13), 4117–4124. https://doi.org/10.1021/ac0501240

Lindinger, C. et al. (2005) ‘Unambiguous identification of volatile organic compounds by proton-transfer-reaction mass-spectrometry (PTR-MS) coupled with GC-MS’, Analytical Chemistry, 77(13), pp. 4117–4124. Available at: https://doi.org/10.1021/ac0501240.

C. Lindinger, P. Pollien, S. Ali, C. Yeretzian, I. Blank, and M. Tilmann, “Unambiguous identification of volatile organic compounds by proton-transfer-reaction mass-spectrometry (PTR-MS) coupled with GC-MS,” Analytical Chemistry, vol. 77, no. 13, pp. 4117–4124, May 2005, doi: 10.1021/ac0501240.

LINDINGER, Christian, Philippe POLLIEN, Santo ALI, Chahan YERETZIAN, Imre BLANK und Märk TILMANN, 2005. Unambiguous identification of volatile organic compounds by proton-transfer-reaction mass-spectrometry (PTR-MS) coupled with GC-MS. Analytical Chemistry. 26 Mai 2005. Bd. 77, Nr. 13, S. 4117–4124. DOI 10.1021/ac0501240

Lindinger, Christian, Philippe Pollien, Santo Ali, Chahan Yeretzian, Imre Blank, and Märk Tilmann. 2005. “Unambiguous Identification of Volatile Organic Compounds by Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS) Coupled with GC-MS.” Analytical Chemistry 77 (13): 4117–24. https://doi.org/10.1021/ac0501240.

Lindinger, Christian, et al. “Unambiguous Identification of Volatile Organic Compounds by Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS) Coupled with GC-MS.” Analytical Chemistry, vol. 77, no. 13, May 2005, pp. 4117–24, https://doi.org/10.1021/ac0501240.