Title: Unambiguous identification of volatile organic compounds by proton-transfer-reaction mass-spectrometry (PTR-MS) coupled with GC-MS
Authors : Lindinger, Christian
Pollien, Philippe
Ali, Santo
Yeretzian, Chahan
Blank, Imre
Tilmann, Märk
Published in : Analytical Chemistry
Volume(Issue) : 77
Issue : 13
Pages : 4117
Pages to: 4124
Publisher / Ed. Institution : American Chemical Society
Publisher / Ed. Institution: Columbus
Issue Date: 26-May-2005
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : PTR-MS
Subject (DDC) : 540: Chemistry
Abstract: Interest in on-line measurements of volatile organic compounds (VOCs) is increasing, as sensitive, compact, and affordable direct inlet mass spectrometers are becoming available. Proton-transfer reaction mass spectrometry (PTR-MS) distinguishes itself by its high sensitivity (low ppt range), high time resolution (200 ms), little ionization-induced fragmentation, and ionization efficiency independent of the compound to be analyzed. Yet, PTR-MS has a shortcoming. It is a one-dimensional technique that characterizes compounds only via their mass, which is not sufficient for positive identification. Here, we introduce a technical and analytical extension of PTR-MS, which removes this shortcoming, while preserving its salient and unique features. Combining separation of VOCs by gas chromatography (GC) with simultaneous and parallel detection of the GC effluent by PTR-MS and electron impact MS, an unambiguous interpretation of complex PTR-MS spectra becomes feasible. This novel development is discussed on the basis of characteristic performance parameters, such as resolution, linear range, and detection limit. The recently developed drift tube with a reduced reaction volume is crucial to exploit the full potential of the setup. We illustrate the performance of the novel setup by analyzing a complex food system.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1021/ac0501240
ISSN: 1520-6882
URI: https://digitalcollection.zhaw.ch/handle/11475/5468
Appears in Collections:Publikationen Life Sciences und Facility Management

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