Preliminary experience with visualization of intracortical fibers by focused high-resolution diffusion tensor imaging

Järmann, Thomas; De Zanche, Nicolas; Staempfli, P.; Pruessmann, K.P.; Valavanis, A.; Boesiger, P.; Kollias, Spyros

doi:10.3174/ajnr.A0742

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Preliminary experience with visualization of intracortical fibers by focused high-resolution diffusion tensor imaging
Authors:	Järmann, Thomas De Zanche, Nicolas Staempfli, P. Pruessmann, K.P. Valavanis, A. Boesiger, P. Kollias, Spyros
DOI:	10.3174/ajnr.A0742
Published in:	American Journal of Neuroradiology
Volume(Issue):	29
Issue:	1
Page(s):	146
Pages to:	150
Issue Date:	2008
Publisher / Ed. Institution:	American Society of Neuroradiology
ISSN:	0195-6108 1936-959X 1936-959X
Language:	English
Subjects:	Adult; Axons; Brain; Diffusion Magnetic Resonance Imaging; Female; Humans; Image enhancement; Image interpretation, computer-assisted; Imaging, three-dimensional; Male; Nerve fibers; Imaging phantoms; Reproducibility of results; Sensitivity and specificity; Algorithms
Subject (DDC):	616.8: Neurology, diseases of nervous system
Abstract:	Background and Purpose: The inherent low anisotropy of gray matter and the lack of adequate imaging sensitivity and resolution has, so far, impeded depiction of axonal fibers to their intracortical origin or termination. We tested the hypothesis that an experimental approach with high-resolution diffusion tensor imaging (DTI) provides anisotropic data for fiber tractography with sufficient sensitivity to visualize in vivo the fine distribution of white matter bundles at the intracortical level. Materials and Methods: We conducted phantom measurements of signal-to-noise ratio (SNR) and obtained diffusion tensor maps of the occipital lobe in 6 healthy volunteers using a dedicated miniature phased array detector at 3T. We reconstructed virtual fibers using a standard tracking algorithm. Results: The coil array provided a SNR of 8.0 times higher at the head surface compared with a standard quadrature whole head coil. Diffusion tensor maps could be obtained with an in-plane resolution of 0.58 × 0.58 mm2. The axonal trajectories reconstructed from the diffusion data penetrate into the cortical ribbon perpendicular to the pial surface. This is the expected pattern for the terminations of thalamocortical afferent fibers to the middle layers of the occipital cortex and is consistent with the known microstructural organization of the mammalian cerebral cortex. Conclusion: High-resolution DTI reveals intracortical anisotropy with a distinct parallel geometrical order, perpendicular to the pial surface, consistent with structures that may be identified as the terminal afferents in cortical gray matter.
URI:	https://digitalcollection.zhaw.ch/handle/11475/5021
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Engineering
Appears in collections:	Publikationen School of Engineering

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Järmann, T., De Zanche, N., Staempfli, P., Pruessmann, K. P., Valavanis, A., Boesiger, P., & Kollias, S. (2008). Preliminary experience with visualization of intracortical fibers by focused high-resolution diffusion tensor imaging. American Journal of Neuroradiology, 29(1), 146–150. https://doi.org/10.3174/ajnr.A0742

Järmann, T. et al. (2008) ‘Preliminary experience with visualization of intracortical fibers by focused high-resolution diffusion tensor imaging’, American Journal of Neuroradiology, 29(1), pp. 146–150. Available at: https://doi.org/10.3174/ajnr.A0742.

T. Järmann et al., “Preliminary experience with visualization of intracortical fibers by focused high-resolution diffusion tensor imaging,” American Journal of Neuroradiology, vol. 29, no. 1, pp. 146–150, 2008, doi: 10.3174/ajnr.A0742.

JÄRMANN, Thomas, Nicolas DE ZANCHE, P. STAEMPFLI, K.P. PRUESSMANN, A. VALAVANIS, P. BOESIGER und Spyros KOLLIAS, 2008. Preliminary experience with visualization of intracortical fibers by focused high-resolution diffusion tensor imaging. American Journal of Neuroradiology. 2008. Bd. 29, Nr. 1, S. 146–150. DOI 10.3174/ajnr.A0742

Järmann, Thomas, Nicolas De Zanche, P. Staempfli, K.P. Pruessmann, A. Valavanis, P. Boesiger, and Spyros Kollias. 2008. “Preliminary Experience with Visualization of Intracortical Fibers by Focused High-Resolution Diffusion Tensor Imaging.” American Journal of Neuroradiology 29 (1): 146–50. https://doi.org/10.3174/ajnr.A0742.

Järmann, Thomas, et al. “Preliminary Experience with Visualization of Intracortical Fibers by Focused High-Resolution Diffusion Tensor Imaging.” American Journal of Neuroradiology, vol. 29, no. 1, 2008, pp. 146–50, https://doi.org/10.3174/ajnr.A0742.