Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Optimizing signal-to-noise ratio of high-resolution parallel single-shot diffusion-weighted echo-planar imaging at ultrahigh field strengths
Authors: Reischauer, Carolin
Vorburger, Robert S.
Wilm, Bertram J.
Järmann, Thomas
Boesiger, Peter
DOI: 10.1002/mrm.23057
Published in: Magnetic Resonance in Medicine
Volume(Issue): 67
Issue: 3
Pages: 679
Pages to: 690
Issue Date: Jun-2012
Publisher / Ed. Institution: Wiley
ISSN: 0740-3194
Language: English
Subjects: Adult; Brain mapping; Computer simulation; Diffusion Magnetic Resonance Imaging; Echo-Planar Imaging; Female; Humans; Image processing, computer-assisted; Male; Models, theoretical; Phantoms, imaging; Signal-to-noise ratio
Subject (DDC): 616: Internal medicine and diseases
Abstract: The potential signal-to-noise ratio (SNR) gain at ultrahigh field strengths offers the promise of higher image resolution in single-shot diffusion-weighted echo-planar imaging the challenge being reduced T(2) and T(2) * relaxation times and increased B(0) inhomogeneity which lead to geometric distortions and image blurring. These can be addressed using parallel imaging (PI) methods for which a greater range of feasible reduction factors has been predicted at ultrahigh field strengths-the tradeoff being an associated SNR loss. Using comprehensive simulations, the SNR of high-resolution diffusion-weighted echo-planar imaging in combination with spin-echo and stimulated-echo acquisition is explored at 7 T and compared to 3 T. To this end, PI performance is simulated for coil arrays with a variable number of circular coil elements. Beyond that, simulations of the point spread function are performed to investigate the actual image resolution. When higher PI reduction factors are applied at 7 T to address increased image distortions, high-resolution imaging benefits SNR-wise only at relatively low PI reduction factors. On the contrary, it features generally higher image resolutions than at 3 T due to smaller point spread functions. The SNR simulations are confirmed by phantom experiments. Finally, high-resolution in vivo images of a healthy volunteer are presented which demonstrate the feasibility of higher PI reduction factors at 7 T in practice.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: School of Engineering
Appears in Collections:Publikationen School of Engineering

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