|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Optimizing signal-to-noise ratio of high-resolution parallel single-shot diffusion-weighted echo-planar imaging at ultrahigh field strengths|
Vorburger, Robert S.
Wilm, Bertram J.
|Published in:||Magnetic Resonance in Medicine|
|Publisher / Ed. Institution:||Wiley|
|Subjects:||Adult; Brain mapping; Computer simulation; Diffusion Magnetic Resonance Imaging; Echo-Planar Imaging; Female; Humans; Image processing, computer-assisted; Male; Models, theoretical; Phantoms, imaging; Signal-to-noise ratio|
|Subject (DDC):||616: Internal medicine and diseases|
|Abstract:||The potential signal-to-noise ratio (SNR) gain at ultrahigh field strengths offers the promise of higher image resolution in single-shot diffusion-weighted echo-planar imaging the challenge being reduced T(2) and T(2) * relaxation times and increased B(0) inhomogeneity which lead to geometric distortions and image blurring. These can be addressed using parallel imaging (PI) methods for which a greater range of feasible reduction factors has been predicted at ultrahigh field strengths-the tradeoff being an associated SNR loss. Using comprehensive simulations, the SNR of high-resolution diffusion-weighted echo-planar imaging in combination with spin-echo and stimulated-echo acquisition is explored at 7 T and compared to 3 T. To this end, PI performance is simulated for coil arrays with a variable number of circular coil elements. Beyond that, simulations of the point spread function are performed to investigate the actual image resolution. When higher PI reduction factors are applied at 7 T to address increased image distortions, high-resolution imaging benefits SNR-wise only at relatively low PI reduction factors. On the contrary, it features generally higher image resolutions than at 3 T due to smaller point spread functions. The SNR simulations are confirmed by phantom experiments. Finally, high-resolution in vivo images of a healthy volunteer are presented which demonstrate the feasibility of higher PI reduction factors at 7 T in practice.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||School of Engineering|
|Appears in Collections:||Publikationen School of Engineering|
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