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dc.contributor.authorSchoonman, Guus G-
dc.contributor.authorSándor, Peter S-
dc.contributor.authorNirkko, Arto C-
dc.contributor.authorLange, Thomas-
dc.contributor.authorJärmann, Thomas-
dc.contributor.authorDydak, Ulrike-
dc.contributor.authorKremer, Christine-
dc.contributor.authorFerrari, Michel D-
dc.contributor.authorBoesiger, Peter-
dc.contributor.authorBaumgartner, Ralf W-
dc.date.accessioned2018-04-10T14:06:22Z-
dc.date.available2018-04-10T14:06:22Z-
dc.date.issued2007-05-
dc.identifier.issn0271-678Xde_CH
dc.identifier.issn1559-7016de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/4991-
dc.description.abstractAcute mountain sickness is common among not acclimatized persons ascending to high altitude; the underlying mechanism is unknown, but may be related to cerebral edema. Nine healthy male students were studied before and after 6-h exposure to isobaric hypoxia. Subjects inhaled room air enriched with N(2) to obtain arterial O(2) saturation values of 75 to 80%. Acute mountain sickness was assessed with the environmental symptom questionnaire, and cerebral edema with 3 T magnetic resonance imaging in 18 regions of interest in the cerebral white matter. The main outcome measures were development of intra- and extracellular cerebral white matter edema assessed by visual inspection and quantitative analysis of apparent diffusion coefficients derived from diffusion-weighted imaging, and B0 signal intensities derived from T2-weighted imaging. Seven of nine subjects developed acute mountain sickness. Mean apparent diffusion coefficient increased 2.12% (baseline, 0.80+/-0.09; 6 h hypoxia, 0.81+/-0.09; P=0.034), and mean B0 signal intensity increased 4.56% (baseline, 432.1+/-98.2; 6 h hypoxia, 450.7+/-102.5; P<0.001). Visual inspection of magnetic resonance images failed to reveal cerebral edema. Cerebral acute mountain sickness scores showed a negative correlation with relative changes of apparent diffusion coefficients (r=-0.83, P=0.006); there was no correlation with relative changes of B0 signal intensities. In conclusion, isobaric hypoxia is associated with mild extracellular (vasogenic) cerebral edema irrespective of the presence of acute mountain sickness in most subjects, and severe acute mountain sickness with additional mild intracellular (cytotoxic) cerebral edema.de_CH
dc.language.isoende_CH
dc.publisherSagede_CH
dc.relation.ispartofJournal of Cerebral Blood Flow & Metabolismde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAcute diseasede_CH
dc.subjectAdultde_CH
dc.subjectAltitude sicknessde_CH
dc.subjectBrain edemade_CH
dc.subjectCerebrumde_CH
dc.subjectHumansde_CH
dc.subjectHypoxiade_CH
dc.subjectMalede_CH
dc.subjectRadiographyde_CH
dc.subjectTime factorsde_CH
dc.subjectMagnetic Resonance Imagingde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleHypoxia-induced acute mountain sickness is associated with intracellular cerebral edema : a 3 T magnetic resonance imaging studyde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
dc.identifier.doi10.1038/sj.jcbfm.9600513de_CH
dc.identifier.pmid17519973de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end206de_CH
zhaw.pages.start198de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume28de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in Collections:Publikationen School of Engineering

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