Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
Art der Begutachtung: Peer review (Publikation)
Titel: Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema : a 3 T magnetic resonance imaging study
Autor/-in: Schoonman, Guus G
Sándor, Peter S
Nirkko, Arto C
Lange, Thomas
Järmann, Thomas
Dydak, Ulrike
Kremer, Christine
Ferrari, Michel D
Boesiger, Peter
Baumgartner, Ralf W
DOI: 10.1038/sj.jcbfm.9600513
Erschienen in: Journal of Cerebral Blood Flow & Metabolism
Band(Heft): 28
Heft: 1
Seiten: 198
Seiten bis: 206
Erscheinungsdatum: Mai-2007
Verlag / Hrsg. Institution: Sage
ISSN: 0271-678X
1559-7016
Sprache: Englisch
Schlagwörter: Acute disease; Adult; Altitude sickness; Brain edema; Cerebrum; Humans; Hypoxia; Male; Radiography; Time factors; Magnetic Resonance Imaging
Fachgebiet (DDC): 616: Innere Medizin und Krankheiten
Zusammenfassung: Acute mountain sickness is common among not acclimatized persons ascending to high altitude; the underlying mechanism is unknown, but may be related to cerebral edema. Nine healthy male students were studied before and after 6-h exposure to isobaric hypoxia. Subjects inhaled room air enriched with N(2) to obtain arterial O(2) saturation values of 75 to 80%. Acute mountain sickness was assessed with the environmental symptom questionnaire, and cerebral edema with 3 T magnetic resonance imaging in 18 regions of interest in the cerebral white matter. The main outcome measures were development of intra- and extracellular cerebral white matter edema assessed by visual inspection and quantitative analysis of apparent diffusion coefficients derived from diffusion-weighted imaging, and B0 signal intensities derived from T2-weighted imaging. Seven of nine subjects developed acute mountain sickness. Mean apparent diffusion coefficient increased 2.12% (baseline, 0.80+/-0.09; 6 h hypoxia, 0.81+/-0.09; P=0.034), and mean B0 signal intensity increased 4.56% (baseline, 432.1+/-98.2; 6 h hypoxia, 450.7+/-102.5; P<0.001). Visual inspection of magnetic resonance images failed to reveal cerebral edema. Cerebral acute mountain sickness scores showed a negative correlation with relative changes of apparent diffusion coefficients (r=-0.83, P=0.006); there was no correlation with relative changes of B0 signal intensities. In conclusion, isobaric hypoxia is associated with mild extracellular (vasogenic) cerebral edema irrespective of the presence of acute mountain sickness in most subjects, and severe acute mountain sickness with additional mild intracellular (cytotoxic) cerebral edema.
URI: https://digitalcollection.zhaw.ch/handle/11475/4991
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): Lizenz gemäss Verlagsvertrag
Departement: School of Engineering
Enthalten in den Sammlungen:Publikationen School of Engineering

Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.


Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.