Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-3558| Publication type: | Conference paper |
| Type of review: | Peer review (abstract) |
| Title: | Kinetic model for dose equivalent : an efficient way to predict systems response of irradiated cells |
| Authors: | Scheidegger, Stephan Füchslin, Rudolf Marcel |
| DOI: | 10.21256/zhaw-3558 |
| Proceedings: | Proceedings of ASIM 2011 : Grundlagen, Methoden und Anwendungen in Modellbildung und Simulation |
| Editors of the parent work: | Bödi, Richard Maurer, Werner |
| Conference details: | 21. Symposium Simulationstechnik (ASIM 2011), Winterthur, 7-9 September 2011 |
| Issue Date: | 2011 |
| Publisher / Ed. Institution: | Arbeitsgemeinschaft Simulation |
| ISBN: | 978-3-905745-44-3 |
| Language: | English |
| Subjects: | Radiation; Radiobiology; Emergence; Dose equivalent |
| Subject (DDC): | 615: Pharmacology and therapeutics |
| Abstract: | The response of tumours onto ionizing radiation cannot be fully understood by commonly used radiobiological models. The reason may lie in the complex structure of the cellular systems which show a high degree of compartmentalisation and which is characterised by a network of interacting processes at different time scales. To access the dynamic response of cells onto radiation, compartmental models based on a biological dose equivalent can be used. Two different models (T-LQ- and T-IR-model) are used to fit experimental data of the clonogenic survival of irradiated cells at very high dose rates. The models reveal the correct dose rate dependence over a wide range of the parameter space when adapting the kinetic constants to the dose rate. This adaption could be an indication for the multi-scale structure of the system. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/4141 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | School of Engineering |
| Appears in collections: | Publikationen School of Engineering |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2011_Scheidegger_Kinetic model_ASIM.pdf | 90.04 kB | Adobe PDF |  View/Open |
Show full item record
Scheidegger, S., & Füchslin, R. M. (2011). Kinetic model for dose equivalent : an efficient way to predict systems response of irradiated cells [Conference paper]. In R. Bödi & W. Maurer (Eds.), Proceedings of ASIM 2011 : Grundlagen, Methoden und Anwendungen in Modellbildung und Simulation. Arbeitsgemeinschaft Simulation. https://doi.org/10.21256/zhaw-3558
Scheidegger, S. and Füchslin, R.M. (2011) ‘Kinetic model for dose equivalent : an efficient way to predict systems response of irradiated cells’, in R. Bödi and W. Maurer (eds) Proceedings of ASIM 2011 : Grundlagen, Methoden und Anwendungen in Modellbildung und Simulation. Arbeitsgemeinschaft Simulation. Available at: https://doi.org/10.21256/zhaw-3558.
S. Scheidegger and R. M. Füchslin, “Kinetic model for dose equivalent : an efficient way to predict systems response of irradiated cells,” in Proceedings of ASIM 2011 : Grundlagen, Methoden und Anwendungen in Modellbildung und Simulation, 2011. doi: 10.21256/zhaw-3558.
SCHEIDEGGER, Stephan und Rudolf Marcel FÜCHSLIN, 2011. Kinetic model for dose equivalent : an efficient way to predict systems response of irradiated cells. In: Richard BÖDI und Werner MAURER (Hrsg.), Proceedings of ASIM 2011 : Grundlagen, Methoden und Anwendungen in Modellbildung und Simulation. Conference paper. Arbeitsgemeinschaft Simulation. 2011. ISBN 978-3-905745-44-3
Scheidegger, Stephan, and Rudolf Marcel Füchslin. 2011. “Kinetic Model for Dose Equivalent : An Efficient Way to Predict Systems Response of Irradiated Cells.” Conference paper. In Proceedings of ASIM 2011 : Grundlagen, Methoden Und Anwendungen in Modellbildung Und Simulation, edited by Richard Bödi and Werner Maurer. Arbeitsgemeinschaft Simulation. https://doi.org/10.21256/zhaw-3558.
Scheidegger, Stephan, and Rudolf Marcel Füchslin. “Kinetic Model for Dose Equivalent : An Efficient Way to Predict Systems Response of Irradiated Cells.” Proceedings of ASIM 2011 : Grundlagen, Methoden Und Anwendungen in Modellbildung Und Simulation, edited by Richard Bödi and Werner Maurer, Arbeitsgemeinschaft Simulation, 2011, https://doi.org/10.21256/zhaw-3558.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.