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Title: Kinetic model for dose equivalent : an efficient way to predict systems response of irradiated cells
Authors : Scheidegger, Stephan
Füchslin, Rudolf Marcel
Proceedings: Proceedings of ASIM 2011 : Grundlagen, Methoden und Anwendungen in Modellbildung und Simulation
Conference details: ASIM 2011: 21. Symposium Simulationstechnik, Arbeitsgemeinschaft Simulation, Winterthur, 7.-9. September 2011
Editors of the parent work: Bödi, Richard
Maurer, Werner
Publisher / Ed. Institution : Arbeitsgemeinschaft Simulation
Issue Date: 2011
License (according to publishing contract) : Licence according to publishing contract
Type of review: Not specified
Language : English
Subjects : Radiation; Radiobiology; Emergence; Dose equivalent
Subject (DDC) : 615: Pharmacology and therapeutics
Abstract: The response of tumours onto ionizing radiation cannot be fully understood by commonly used radiobiological models. The reason may lie in the complex structure of the cellular systems which show a high degree of compartmentalisation and which is characterised by a network of interacting processes at different time scales. To access the dynamic response of cells onto radiation, compartmental models based on a biological dose equivalent can be used. Two different models (T-LQ- and T-IR-model) are used to fit experimental data of the clonogenic survival of irradiated cells at very high dose rates. The models reveal the correct dose rate dependence over a wide range of the parameter space when adapting the kinetic constants to the dose rate. This adaption could be an indication for the multi-scale structure of the system.
Departement: School of Engineering
Publication type: Conference Paper
DOI : 10.21256/zhaw-3558
ISBN: 978-3-905745-44-3
Appears in Collections:Publikationen School of Engineering

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