Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children : importance of gender and associations with behavioral/emotional difficulties

Hatzinger, Martin; Brand, Serge; Perren, Sonja; von Wyl, Agnes; von Klitzing, Kai; Holsboer-Trachsler, Edith

doi:10.1016/j.jpsychires.2006.07.012

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children : importance of gender and associations with behavioral/emotional difficulties
Authors:	Hatzinger, Martin Brand, Serge Perren, Sonja von Wyl, Agnes von Klitzing, Kai Holsboer-Trachsler, Edith
DOI:	10.1016/j.jpsychires.2006.07.012
Published in:	Journal of Psychiatric Research
Volume(Issue):	41
Issue:	10
Page(s):	861
Pages to:	870
Issue Date:	Nov-2007
Publisher / Ed. Institution:	Elsevier
ISSN:	0022-3956 1879-1379
Language:	English
Subjects:	Child; HPA system; Prediction; Gender
Subject (DDC):	155: Differential and developmental psychology 616.8: Neurology, diseases of nervous system 618.92: Pediatrics
Abstract:	The current cross-sectional study investigated basal and stress-challenged hypothalamic-pituitary-adrenocortical (HPA) system function in 102 five-year old kindergarten children (59 boys, 43 girls) who had been assessed by a comprehensive psychological and behavioral test battery. Baseline HPA system activity was significantly increased in girls when compared to boys (p < 0.001). Furthermore, basal HPA system activity predicted a high hormonal release during stress with – again – girls showing higher hormonal responses than boys (p < 0.01). Importantly, increased HPA system activity (baseline and stress-challenged) was significantly associated with hyperactivity/impulsivity and emotional problems in boys and with positive emotions in girls (p < 0.05). These results suggest an occurrence of neurobiological alterations early in development. The observed neurobiological changes are gender specific already at the age of 5 years. Prospective long-term follow up of the identified subjects with HPA axis alterations will clarify if these markers are predictive for the onset of psychiatric disorders.
URI:	https://digitalcollection.zhaw.ch/handle/11475/3991
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

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Hatzinger, M., Brand, S., Perren, S., von Wyl, A., von Klitzing, K., & Holsboer-Trachsler, E. (2007). Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children : importance of gender and associations with behavioral/emotional difficulties. Journal of Psychiatric Research, 41(10), 861–870. https://doi.org/10.1016/j.jpsychires.2006.07.012

Hatzinger, M. et al. (2007) ‘Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children : importance of gender and associations with behavioral/emotional difficulties’, Journal of Psychiatric Research, 41(10), pp. 861–870. Available at: https://doi.org/10.1016/j.jpsychires.2006.07.012.

M. Hatzinger, S. Brand, S. Perren, A. von Wyl, K. von Klitzing, and E. Holsboer-Trachsler, “Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children : importance of gender and associations with behavioral/emotional difficulties,” Journal of Psychiatric Research, vol. 41, no. 10, pp. 861–870, Nov. 2007, doi: 10.1016/j.jpsychires.2006.07.012.

HATZINGER, Martin, Serge BRAND, Sonja PERREN, Agnes VON WYL, Kai VON KLITZING und Edith HOLSBOER-TRACHSLER, 2007. Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children : importance of gender and associations with behavioral/emotional difficulties. Journal of Psychiatric Research. November 2007. Bd. 41, Nr. 10, S. 861–870. DOI 10.1016/j.jpsychires.2006.07.012

Hatzinger, Martin, Serge Brand, Sonja Perren, Agnes von Wyl, Kai von Klitzing, and Edith Holsboer-Trachsler. 2007. “Hypothalamic-Pituitary-Adrenocortical (HPA) Activity in Kindergarten Children : Importance of Gender and Associations with Behavioral/Emotional Difficulties.” Journal of Psychiatric Research 41 (10): 861–70. https://doi.org/10.1016/j.jpsychires.2006.07.012.

Hatzinger, Martin, et al. “Hypothalamic-Pituitary-Adrenocortical (HPA) Activity in Kindergarten Children : Importance of Gender and Associations with Behavioral/Emotional Difficulties.” Journal of Psychiatric Research, vol. 41, no. 10, Nov. 2007, pp. 861–70, https://doi.org/10.1016/j.jpsychires.2006.07.012.