Title: Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children : importance of gender and associations with behavioral/emotional difficulties
Authors : Hatzinger, Martin
Brand, Serge
Perren, Sonja
von Wyl, Agnes
von Klitzing, Kai
Holsboer-Trachsler, Edith
Published in : Journal of Psychiatric Research
Volume(Issue) : 41
Issue : 10
Pages : 861
Pages to: 870
Publisher / Ed. Institution : Pergamon Press
Issue Date: Nov-2007
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Child; HPA system; Prediction; Gender
Subject (DDC) : 155: Differential and developmental psychology
616.8: Neurology, diseases of nervous system
618.92: Pediatrics
Abstract: The current cross-sectional study investigated basal and stress-challenged hypothalamic–pituitary–adrenocortical (HPA) system function in 102 five-year old kindergarten children (59 boys, 43 girls) who had been assessed by a comprehensive psychological and behavioral test battery. Baseline HPA system activity was significantly increased in girls when compared to boys (p < 0.001). Furthermore, basal HPA system activity predicted a high hormonal release during stress with – again – girls showing higher hormonal responses than boys (p < 0.01). Importantly, increased HPA system activity (baseline and stress-challenged) was significantly associated with hyperactivity/impulsivity and emotional problems in boys and with positive emotions in girls (p < 0.05). These results suggest an occurrence of neurobiological alterations early in development. The observed neurobiological changes are gender specific already at the age of 5 years. Prospective long-term follow up of the identified subjects with HPA axis alterations will clarify if these markers are predictive for the onset of psychiatric disorders.
Departement: Angewandte Psychologie
Organisational Unit: Psychological Institute (PI)
Publication type: Article in scientific Journal
DOI : 10.1016/j.jpsychires.2006.07.012
ISSN: 0022-3956
URI: https://digitalcollection.zhaw.ch/handle/11475/3991
Appears in Collections:Publikationen Angewandte Psychologie

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