Title: Where does the oxygen go? : kLa measurement in bioreactors
Authors : Backoff, Tobias
Malig, Jennifer
Sören, Werner
Eibl, Dieter
John, Gernot T.
Published in : G.I.T. Laboratory Journal
Volume(Issue) : 9
Issue : 10
Pages : 20
Pages to: 21
Publisher / Ed. Institution : G I T Verlag
Publisher / Ed. Institution: Weinheim
Issue Date: 25-Jan-2013
License (according to publishing contract) : Licence according to publishing contract
Type of review: Not specified
Language : English
Subject (DDC) : 660: Chemical engineering
Abstract: Small plastic tubes are available as single-use bioreactors for cell cultivation as a cost effective alternative to larger scale cultivation systems. However, the characteristics of the tubes with regard to oxygen transfer have hardly been investigated. Using a specially adapted shake flask reader (SFR) and chemical optical sensors with rapid response time, the volumetric oxygen mass transfer coefficient (kLa) for tube systems was determined. The characteristics of these cultivation vessels were investigated more closely, which represents an important step towards defined screening processes by monitoring oxygen in bioreactors.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
ISSN: 1611-6038
URI: http://www.laboratory-journal.com/applications/biological-methods/where-does-oxygen-go
Appears in Collections:Publikationen Life Sciences und Facility Management

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