| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Effect of high dose per pulse flattening filter-free beams on cancer cell survival |
| Autor/-in: | Lohse, Ines Lang, Stephanie Hrbacek, Jan Scheidegger, Stephan Bodis, Stephan Sanchez-Macedo, Nadia Feng, Jianhua Lütolf, Urs M. Zaugg, Kathrin |
| DOI: | 10.1016/j.radonc.2011.05.072 |
| Erschienen in: | Radiotherapy & Oncology |
| Band(Heft): | 101 |
| Heft: | 1 |
| Seite(n): | 226 |
| Seiten bis: | 232 |
| Erscheinungsdatum: | 2011 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 0167-8140 1879-0887 |
| Sprache: | Englisch |
| Schlagwörter: | Cancer cell survival; Flattening filter; Radiotherapy; High dose |
| Fachgebiet (DDC): | 571: Physiologie und verwandte Themen 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | Purpose: To investigate if there is a statistically significant difference in cancer cell survival using a high dose per pulse flattening filter-free (FFF) beam compared to a standard flattened beam. Material and methods: To validate the radiobiological effect of the flattened and FFF beam, two glioblastoma cell lines were treated with either 5 or 10 Gy using different dose rates. Dose verification was performed and colony formation assays were carried out. To compare the predictability of our data, radiobiological models were included. Results: The results presented here demonstrate that irradiation of glioblastoma cell lines using the FFF beam is more efficient in reducing clonogenic cell survival than the standard flattened beam, an effect which becomes more significant the higher the single dose. Interestingly, in our experimental setting, the radiobiological effect of the FFF beam is dependent on dose per pulse rather than on delivery time. The used radiobiological models are able to describe the observed dose rate dependency between 6 and 24 Gy/min. Conclusion: The results presented here show that dose per pulse might become a crucial factor which influences cancer cell survival. Using high dose rates, currently used radiobiological models as well as molecular mechanisms involved urgently need to be re-examined. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/3542 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | School of Engineering |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
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Lohse, I., Lang, S., Hrbacek, J., Scheidegger, S., Bodis, S., Sanchez-Macedo, N., Feng, J., Lütolf, U. M., & Zaugg, K. (2011). Effect of high dose per pulse flattening filter-free beams on cancer cell survival. Radiotherapy & Oncology, 101(1), 226–232. https://doi.org/10.1016/j.radonc.2011.05.072
Lohse, I. et al. (2011) ‘Effect of high dose per pulse flattening filter-free beams on cancer cell survival’, Radiotherapy & Oncology, 101(1), pp. 226–232. Available at: https://doi.org/10.1016/j.radonc.2011.05.072.
I. Lohse et al., “Effect of high dose per pulse flattening filter-free beams on cancer cell survival,” Radiotherapy & Oncology, vol. 101, no. 1, pp. 226–232, 2011, doi: 10.1016/j.radonc.2011.05.072.
LOHSE, Ines, Stephanie LANG, Jan HRBACEK, Stephan SCHEIDEGGER, Stephan BODIS, Nadia SANCHEZ-MACEDO, Jianhua FENG, Urs M. LÜTOLF und Kathrin ZAUGG, 2011. Effect of high dose per pulse flattening filter-free beams on cancer cell survival. Radiotherapy & Oncology. 2011. Bd. 101, Nr. 1, S. 226–232. DOI 10.1016/j.radonc.2011.05.072
Lohse, Ines, Stephanie Lang, Jan Hrbacek, Stephan Scheidegger, Stephan Bodis, Nadia Sanchez-Macedo, Jianhua Feng, Urs M. Lütolf, and Kathrin Zaugg. 2011. “Effect of High Dose per Pulse Flattening Filter-Free Beams on Cancer Cell Survival.” Radiotherapy & Oncology 101 (1): 226–32. https://doi.org/10.1016/j.radonc.2011.05.072.
Lohse, Ines, et al. “Effect of High Dose per Pulse Flattening Filter-Free Beams on Cancer Cell Survival.” Radiotherapy & Oncology, vol. 101, no. 1, 2011, pp. 226–32, https://doi.org/10.1016/j.radonc.2011.05.072.
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