Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach

Scheidegger, Stephan; Fuchs, Hans Ulrich; Zaugg, Kathrin; Bodis, Stephan; Füchslin, Rudolf Marcel

doi:10.21256/zhaw-1765

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1765

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach
Authors:	Scheidegger, Stephan Fuchs, Hans Ulrich Zaugg, Kathrin Bodis, Stephan Füchslin, Rudolf Marcel
DOI:	10.21256/zhaw-1765 10.1155/2013/587543
Published in:	Computational and Mathematical Methods in Medicine
Volume(Issue):	2013
Issue:	587543
Issue Date:	2013
Publisher / Ed. Institution:	Hindawi
ISSN:	1748-670X 1748-6718
Language:	English
Subject (DDC):	615: Pharmacology and therapeutics
Abstract:	In order to overcome the limitations of the linear-quadratic model and include synergistic effects of heat and radiation, a novel radiobiological model is proposed. The model is based on a chain of cell populations which are characterized by the number of radiation induced damages (hits). Cells can shift downward along the chain by collecting hits and upward by a repair process. The repair process is governed by a repair probability which depends upon state variables used for a simplistic description of the impact of heat and radiation upon repair proteins. Based on the parameters used, populations up to 4-5 hits are relevant for the calculation of the survival. The model describes intuitively the mathematical behaviour of apoptotic and non-apoptotic cell death. Linear-quadratic-linear behaviour of the logarithmic cell survival, fractionation, and (with one exception) the dose rate dependencies are described correctly. The model covers the time gap dependence of the synergistic cell killing due to combined application of heat and radiation, but further validation of the proposed approach based on experimental data is needed. However, the model offers a work bench for testing different biological concepts of damage induction, repair, and statistical approaches for calculating the variables of state.
URI:	https://digitalcollection.zhaw.ch/handle/11475/3402
Fulltext version:	Published version
License (according to publishing contract):	CC BY 3.0: Attribution 3.0 Unported
Departement:	School of Engineering
Organisational Unit:	Institute of Applied Mathematics and Physics (IAMP)
Appears in collections:	Publikationen School of Engineering

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Scheidegger, S., Fuchs, H. U., Zaugg, K., Bodis, S., & Füchslin, R. M. (2013). Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach. Computational and Mathematical Methods in Medicine, 2013(587543). https://doi.org/10.21256/zhaw-1765

Scheidegger, S. et al. (2013) ‘Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach’, Computational and Mathematical Methods in Medicine, 2013(587543). Available at: https://doi.org/10.21256/zhaw-1765.

S. Scheidegger, H. U. Fuchs, K. Zaugg, S. Bodis, and R. M. Füchslin, “Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach,” Computational and Mathematical Methods in Medicine, vol. 2013, no. 587543, 2013, doi: 10.21256/zhaw-1765.

SCHEIDEGGER, Stephan, Hans Ulrich FUCHS, Kathrin ZAUGG, Stephan BODIS und Rudolf Marcel FÜCHSLIN, 2013. Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach. Computational and Mathematical Methods in Medicine. 2013. Bd. 2013, Nr. 587543. DOI 10.21256/zhaw-1765

Scheidegger, Stephan, Hans Ulrich Fuchs, Kathrin Zaugg, Stephan Bodis, and Rudolf Marcel Füchslin. 2013. “Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach.” Computational and Mathematical Methods in Medicine 2013 (587543). https://doi.org/10.21256/zhaw-1765.

Scheidegger, Stephan, et al. “Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach.” Computational and Mathematical Methods in Medicine, vol. 2013, no. 587543, 2013, https://doi.org/10.21256/zhaw-1765.