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https://doi.org/10.21256/zhaw-1692
Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
Art der Begutachtung: | Peer review (Publikation) |
Titel: | Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor |
Autor/-in: | Fischer, Thomas Riedl, Rainer |
DOI: | 10.3390/molecules22091548 10.21256/zhaw-1692 |
Erschienen in: | Molecules |
Band(Heft): | 22 |
Heft: | 9 |
Erscheinungsdatum: | 2017 |
Verlag / Hrsg. Institution: | MDPI |
ISSN: | 1420-3049 1433-1373 |
Sprache: | Englisch |
Schlagwörter: | Medicinal chemistry; Drug discovery; Inhibitor |
Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik |
Zusammenfassung: | Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan. MMP-7 is a validated target for the development of small molecule drugs against cancer. MMP-13 is within the enzyme class the most efficient contributor to type II collagen degeneration and is a validated target in arthritis and cancer. We have developed the dual MMP-7/-13 inhibitor ZHAWOC6941 with IC50-values of 2.2 M (MMP-7) and 1.2 M (MMP-13) that is selective over a broad range of MMP isoforms. It spares MMP-1, -2, -3, -8, -9, -12 and -14, making it a valuable modulator for targeted polypharmacology approaches. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/2895 |
Volltext Version: | Publizierte Version |
Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
Departement: | Life Sciences und Facility Management |
Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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2017_Fischer_Development of a non-hydroxamate dual matrix metalloproteinase_Molecules.pdf | 1.83 MB | Adobe PDF | Öffnen/Anzeigen |
Zur Langanzeige
Fischer, T., & Riedl, R. (2017). Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor. Molecules, 22(9). https://doi.org/10.3390/molecules22091548
Fischer, T. and Riedl, R. (2017) ‘Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor’, Molecules, 22(9). Available at: https://doi.org/10.3390/molecules22091548.
T. Fischer and R. Riedl, “Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor,” Molecules, vol. 22, no. 9, 2017, doi: 10.3390/molecules22091548.
FISCHER, Thomas und Rainer RIEDL, 2017. Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor. Molecules. 2017. Bd. 22, Nr. 9. DOI 10.3390/molecules22091548
Fischer, Thomas, and Rainer Riedl. 2017. “Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.” Molecules 22 (9). https://doi.org/10.3390/molecules22091548.
Fischer, Thomas, and Rainer Riedl. “Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.” Molecules, vol. 22, no. 9, 2017, https://doi.org/10.3390/molecules22091548.
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