Don’t forget the fish : organ damage and hepatic lipid accumulation in carp after feed-borne exposure to DON

Pietsch-Schmied, Constanze

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DC Field	Value	Language
dc.contributor.author	Pietsch-Schmied, Constanze	-
dc.date.accessioned	2018-02-20T16:15:35Z	-
dc.date.available	2018-02-20T16:15:35Z	-
dc.date.issued	2014	-
dc.identifier.uri	https://digitalcollection.zhaw.ch/handle/11475/2894	-
dc.description.abstract	The occurrence of mycotoxins in fish nutrition increasingly gains attention. One of the most important contaminants in fish feeds is deoxynivalenol (DON). The investigations that will be presented show effects of DON on carp (Cyprinus carpio L.) using three different DON concentrations representative for commercial fish feeds including increased lipid peroxidation in liver, head kidney and spleen after four weeks of DON feeding of fish. Most of the effects of DON were reversible by two weeks of feeding the uncontaminated control diet. However, histopathological scoring revealed increased liver damage in DON-treated fish, which persisted even after the recovery phase. Biochemical analyses revealed a significantly higher fat content, and consequently an increased energy content in whole body homogenates of fish treated with the highest DON concentration. This suggests that DON affects nutrient metabolism in carp. Changes of lactate dehydrogenase activity in kidneys and muscle and high lactate levels in serum indicated an effect of DON on anaerobic metabolism. Thus, DON affects liver function and metabolism in carp. Effects on growth and mass of fish were not observed during these 6 weeks lasting experiments, and only marginal DON concentrations were found in muscle and plasma samples. Nevertheless, DON impaired innate immune responses whereby cytotoxic effects of DON partly contributed to this effect. Investigations of acute and chronic responses to DON revealed that the early responses of immune cells include increased expression of pro-inflammatory and anti-inflammatory genes whereas prolonged exposure to DON only led to the activation of anti-inflammatory genes. Consequently, these results raise concern about impaired immune function and animal welfare of fish raised in aquaculture.	de_CH
dc.language.iso	en	de_CH
dc.publisher	Bastiaanse Communication	de_CH
dc.rights	Licence according to publishing contract	de_CH
dc.subject	Aquaculture	de_CH
dc.subject	Health	de_CH
dc.subject	Fish nutrition	de_CH
dc.subject	Mycotoxin	de_CH
dc.subject.ddc	572: Biochemie	de_CH
dc.title	Don’t forget the fish : organ damage and hepatic lipid accumulation in carp after feed-borne exposure to DON	de_CH
dc.type	Konferenz: Sonstiges	de_CH
dcterms.type	Text	de_CH
zhaw.departement	Life Sciences und Facility Management	de_CH
zhaw.organisationalunit	Institut für Umwelt und Natürliche Ressourcen (IUNR)	de_CH
zhaw.publisher.place	Bilthoven	de_CH
zhaw.conference.details	8th Conference - World Mycotoxin Forum, Vienna, Austria, 10-12 November 2014	de_CH
zhaw.funding.eu	No	de_CH
zhaw.originated.zhaw	Yes	de_CH
zhaw.publication.status	publishedVersion	de_CH
zhaw.publication.review	Keine Begutachtung	de_CH
zhaw.webfeed	Aquakultur-Systeme	de_CH
Appears in collections:	Publikationen Life Sciences und Facility Management

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Pietsch-Schmied, C. (2014). Don’t forget the fish : organ damage and hepatic lipid accumulation in carp after feed-borne exposure to DON. 8th Conference - World Mycotoxin Forum, Vienna, Austria, 10-12 November 2014.

Pietsch-Schmied, C. (2014) ‘Don’t forget the fish : organ damage and hepatic lipid accumulation in carp after feed-borne exposure to DON’, in 8th Conference - World Mycotoxin Forum, Vienna, Austria, 10-12 November 2014. Bilthoven: Bastiaanse Communication.

C. Pietsch-Schmied, “Don’t forget the fish : organ damage and hepatic lipid accumulation in carp after feed-borne exposure to DON,” in 8th Conference - World Mycotoxin Forum, Vienna, Austria, 10-12 November 2014, 2014.

PIETSCH-SCHMIED, Constanze, 2014. Don’t forget the fish : organ damage and hepatic lipid accumulation in carp after feed-borne exposure to DON. In: 8th Conference - World Mycotoxin Forum, Vienna, Austria, 10-12 November 2014. Conference presentation. Bilthoven: Bastiaanse Communication. 2014

Pietsch-Schmied, Constanze. 2014. “Don’t Forget the Fish : Organ Damage and Hepatic Lipid Accumulation in Carp after Feed-Borne Exposure to DON.” Conference presentation. In 8th Conference - World Mycotoxin Forum, Vienna, Austria, 10-12 November 2014. Bilthoven: Bastiaanse Communication.

Pietsch-Schmied, Constanze. “Don’t Forget the Fish : Organ Damage and Hepatic Lipid Accumulation in Carp after Feed-Borne Exposure to DON.” 8th Conference - World Mycotoxin Forum, Vienna, Austria, 10-12 November 2014, Bastiaanse Communication, 2014.