Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-1689Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Fischer, Thomas | - |
| dc.contributor.author | Riedl, Rainer | - |
| dc.date.accessioned | 2018-02-16T14:54:50Z | - |
| dc.date.available | 2018-02-16T14:54:50Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.issn | 2191-1363 | de_CH |
| dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/2859 | - |
| dc.description | Zugehöriger Artikel: https://digitalcollection.zhaw.ch/handle/11475/2857 | de_CH |
| dc.description.abstract | The Front Cover picture shows the design of the highly potent and selective inhibitor ZHAWOC5684 bound to its target protein matrix metalloproteinase-13 (MMP-13). The key design principle involves the structure-based positioning of a single fluorine atom to probe water-mediated interactions within the allosteric binding site. In combination with a zinc-binding carboxylic acid fragment blocking the active site this approach delivers a drug-like small molecule inhibitor of MMP-13 with excellent microsomal and plasma stability. | de_CH |
| dc.language.iso | en | de_CH |
| dc.publisher | Wiley | de_CH |
| dc.relation.ispartof | ChemistryOpen | de_CH |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/ | de_CH |
| dc.subject | Medicinal chemistry | de_CH |
| dc.subject | Drug discovery | de_CH |
| dc.subject | Drug design | de_CH |
| dc.subject.ddc | 572: Biochemie | de_CH |
| dc.subject.ddc | 615: Pharmakologie und Therapeutik | de_CH |
| dc.title | Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017) | de_CH |
| dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
| dcterms.type | Text | de_CH |
| zhaw.departement | Life Sciences und Facility Management | de_CH |
| zhaw.organisationalunit | Institut für Chemie und Biotechnologie (ICBT) | de_CH |
| dc.identifier.doi | 10.1002/open.201700043 | de_CH |
| dc.identifier.doi | 10.21256/zhaw-1689 | - |
| zhaw.funding.eu | No | de_CH |
| zhaw.issue | 2 | de_CH |
| zhaw.originated.zhaw | Yes | de_CH |
| zhaw.pages.start | 165 | de_CH |
| zhaw.publication.status | publishedVersion | de_CH |
| zhaw.volume | 6 | de_CH |
| zhaw.publication.review | Peer review (Publikation) | de_CH |
| zhaw.webfeed | CC Drug Discovery | de_CH |
| Appears in collections: | Publikationen Life Sciences und Facility Management | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2017_Fischer_Cover picture_ChemistryOpen.pdf | 316.18 kB | Adobe PDF |  View/Open |
Show simple item record
Fischer, T., & Riedl, R. (2017). Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017). ChemistryOpen, 6(2), 165. https://doi.org/10.1002/open.201700043
Fischer, T. and Riedl, R. (2017) ‘Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017)’, ChemistryOpen, 6(2), p. 165. Available at: https://doi.org/10.1002/open.201700043.
T. Fischer and R. Riedl, “Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017),” ChemistryOpen, vol. 6, no. 2, p. 165, 2017, doi: 10.1002/open.201700043.
FISCHER, Thomas und Rainer RIEDL, 2017. Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017). ChemistryOpen. 2017. Bd. 6, Nr. 2, S. 165. DOI 10.1002/open.201700043
Fischer, Thomas, and Rainer Riedl. 2017. “Cover Picture : Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor (ChemistryOpen 2/2017).” ChemistryOpen 6 (2): 165. https://doi.org/10.1002/open.201700043.
Fischer, Thomas, and Rainer Riedl. “Cover Picture : Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor (ChemistryOpen 2/2017).” ChemistryOpen, vol. 6, no. 2, 2017, p. 165, https://doi.org/10.1002/open.201700043.
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