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https://doi.org/10.21256/zhaw-1689| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017) |
| Authors: | Fischer, Thomas Riedl, Rainer |
| DOI: | 10.1002/open.201700043 10.21256/zhaw-1689 |
| Published in: | ChemistryOpen |
| Volume(Issue): | 6 |
| Issue: | 2 |
| Page(s): | 165 |
| Issue Date: | 2017 |
| Publisher / Ed. Institution: | Wiley |
| ISSN: | 2191-1363 |
| Language: | English |
| Subjects: | Medicinal chemistry; Drug discovery; Drug design |
| Subject (DDC): | 572: Biochemistry 615: Pharmacology and therapeutics |
| Abstract: | The Front Cover picture shows the design of the highly potent and selective inhibitor ZHAWOC5684 bound to its target protein matrix metalloproteinase-13 (MMP-13). The key design principle involves the structure-based positioning of a single fluorine atom to probe water-mediated interactions within the allosteric binding site. In combination with a zinc-binding carboxylic acid fragment blocking the active site this approach delivers a drug-like small molecule inhibitor of MMP-13 with excellent microsomal and plasma stability. |
| Further description: | Zugehöriger Artikel: https://digitalcollection.zhaw.ch/handle/11475/2857 |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2859 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2017_Fischer_Cover picture_ChemistryOpen.pdf | 316.18 kB | Adobe PDF |  View/Open |
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Fischer, T., & Riedl, R. (2017). Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017). ChemistryOpen, 6(2), 165. https://doi.org/10.1002/open.201700043
Fischer, T. and Riedl, R. (2017) ‘Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017)’, ChemistryOpen, 6(2), p. 165. Available at: https://doi.org/10.1002/open.201700043.
T. Fischer and R. Riedl, “Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017),” ChemistryOpen, vol. 6, no. 2, p. 165, 2017, doi: 10.1002/open.201700043.
FISCHER, Thomas und Rainer RIEDL, 2017. Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017). ChemistryOpen. 2017. Bd. 6, Nr. 2, S. 165. DOI 10.1002/open.201700043
Fischer, Thomas, and Rainer Riedl. 2017. “Cover Picture : Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor (ChemistryOpen 2/2017).” ChemistryOpen 6 (2): 165. https://doi.org/10.1002/open.201700043.
Fischer, Thomas, and Rainer Riedl. “Cover Picture : Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor (ChemistryOpen 2/2017).” ChemistryOpen, vol. 6, no. 2, 2017, p. 165, https://doi.org/10.1002/open.201700043.
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