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https://doi.org/10.21256/zhaw-1689| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017) |
| Autor/-in: | Fischer, Thomas Riedl, Rainer |
| DOI: | 10.1002/open.201700043 10.21256/zhaw-1689 |
| Erschienen in: | ChemistryOpen |
| Band(Heft): | 6 |
| Heft: | 2 |
| Seite(n): | 165 |
| Erscheinungsdatum: | 2017 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 2191-1363 |
| Sprache: | Englisch |
| Schlagwörter: | Medicinal chemistry; Drug discovery; Drug design |
| Fachgebiet (DDC): | 572: Biochemie 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | The Front Cover picture shows the design of the highly potent and selective inhibitor ZHAWOC5684 bound to its target protein matrix metalloproteinase-13 (MMP-13). The key design principle involves the structure-based positioning of a single fluorine atom to probe water-mediated interactions within the allosteric binding site. In combination with a zinc-binding carboxylic acid fragment blocking the active site this approach delivers a drug-like small molecule inhibitor of MMP-13 with excellent microsomal and plasma stability. |
| Weitere Angaben: | Zugehöriger Artikel: https://digitalcollection.zhaw.ch/handle/11475/2857 |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2859 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY-NC-ND 4.0: Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2017_Fischer_Cover picture_ChemistryOpen.pdf | 316.18 kB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Fischer, T., & Riedl, R. (2017). Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017). ChemistryOpen, 6(2), 165. https://doi.org/10.1002/open.201700043
Fischer, T. and Riedl, R. (2017) ‘Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017)’, ChemistryOpen, 6(2), p. 165. Available at: https://doi.org/10.1002/open.201700043.
T. Fischer and R. Riedl, “Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017),” ChemistryOpen, vol. 6, no. 2, p. 165, 2017, doi: 10.1002/open.201700043.
FISCHER, Thomas und Rainer RIEDL, 2017. Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017). ChemistryOpen. 2017. Bd. 6, Nr. 2, S. 165. DOI 10.1002/open.201700043
Fischer, Thomas, and Rainer Riedl. 2017. “Cover Picture : Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor (ChemistryOpen 2/2017).” ChemistryOpen 6 (2): 165. https://doi.org/10.1002/open.201700043.
Fischer, Thomas, and Rainer Riedl. “Cover Picture : Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor (ChemistryOpen 2/2017).” ChemistryOpen, vol. 6, no. 2, 2017, p. 165, https://doi.org/10.1002/open.201700043.
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