Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp

Pietsch-Schmied, Constanze; Burkhardt-Holm, Patricia

doi:10.3920/WMJ2015.1879

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp
Authors:	Pietsch-Schmied, Constanze Burkhardt-Holm, Patricia
DOI:	10.3920/WMJ2015.1879
Published in:	World Mycotoxin Journal
Volume(Issue):	8
Issue:	5
Page(s):	619
Pages to:	627
Issue Date:	2015
Publisher / Ed. Institution:	Wageningen Academic Publishers
ISSN:	1875-0710 1875-0796
Language:	English
Subject (DDC):	571: Physiology and related subjects 630: Agriculture
Abstract:	Deoxynivalenol (DON) is a frequent contaminant of feeds in aquaculture, but the consequences of this contamination have rarely been evaluated. Previous studies on carp indicated effects of DON on liver function and histology after four weeks of feeding. The present study aimed to unravel the time course of liver responses of carp to orally applied DON. Therefore, liver enzyme activities and histology have been investigated after 7, 14, 26 and 56 days of DON feeding. The acute response comprises down-regulation of biotransformation enzymes, whereas the chronic response to DON is characterised by activation of alanine aminotransferase which indicates damage to liver tissue. Examination of histological sections of liver tissue revealed that changes such as fat aggregation, vacuolisation and hyperaemia were present after 14 and 26 days of exposure to DON but not thereafter. Several enzymes involved in glutathione cycling and reduction of oxidative stress were found to be reduced after 26 and 56 days of DON feeding. The results suggest that supporting the antioxidative system, e.g. by using glutathione-enriched yeast extracts as a food additive, might be successful in preventing the effects of DON in carp. This is the basis of a fundamental hypothesis since DON contamination of fish feed leads to pronounced effects on liver histology and liver enzyme activities which may also cause changes in the normal liver metabolism of endogenous and xenobiotic compounds.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2848
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Natural Resource Sciences (IUNR)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Pietsch-Schmied, C., & Burkhardt-Holm, P. (2015). Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp. World Mycotoxin Journal, 8(5), 619–627. https://doi.org/10.3920/WMJ2015.1879

Pietsch-Schmied, C. and Burkhardt-Holm, P. (2015) ‘Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp’, World Mycotoxin Journal, 8(5), pp. 619–627. Available at: https://doi.org/10.3920/WMJ2015.1879.

C. Pietsch-Schmied and P. Burkhardt-Holm, “Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp,” World Mycotoxin Journal, vol. 8, no. 5, pp. 619–627, 2015, doi: 10.3920/WMJ2015.1879.

PIETSCH-SCHMIED, Constanze und Patricia BURKHARDT-HOLM, 2015. Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp. World Mycotoxin Journal. 2015. Bd. 8, Nr. 5, S. 619–627. DOI 10.3920/WMJ2015.1879

Pietsch-Schmied, Constanze, and Patricia Burkhardt-Holm. 2015. “Feed-Borne Exposure to Deoxynivalenol Leads to Acute and Chronic Effects on Liver Enzymes and Histology in Carp.” World Mycotoxin Journal 8 (5): 619–27. https://doi.org/10.3920/WMJ2015.1879.

Pietsch-Schmied, Constanze, and Patricia Burkhardt-Holm. “Feed-Borne Exposure to Deoxynivalenol Leads to Acute and Chronic Effects on Liver Enzymes and Histology in Carp.” World Mycotoxin Journal, vol. 8, no. 5, 2015, pp. 619–27, https://doi.org/10.3920/WMJ2015.1879.