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Title: Targeting antibiotic resistance
Authors : Chellat, Mathieu F.
Raguž, Luka
Riedl, Rainer
Published in : Angewandte Chemie : international Edition
Volume(Issue) : 55
Issue : 23
Pages : 6600
Pages to: 6626
Publisher / Ed. Institution : Wiley
Issue Date: 2016
Language : Englisch / English
Subjects : Medicinal chemistry; Antibiotic resistance; Drug design
Subject (DDC) : 540: Chemie
615: Pharmakologie und Therapeutik
Abstract: Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even lastresort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled “Combat drug resistance: no action today means no cure tomorrow” triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.
Departement: Life Sciences und Facility Management
Publication type: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
Type of review: Peer review (Publikation)
DOI : 10.1002/anie.201506818
ISSN: 1521-3773
License (according to publishing contract) : CC BY-NC-ND 4.0: Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International
Appears in Collections:Publikationen Life Sciences und Facility Management

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