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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Targeting antibiotic resistance
Authors: Chellat, Mathieu F.
Raguž, Luka
Riedl, Rainer
DOI: 10.21256/zhaw-1682
Published in: Angewandte Chemie: International Edition
Volume(Issue): 55
Issue: 23
Pages: 6600
Pages to: 6626
Issue Date: 2016
Publisher / Ed. Institution: Wiley
ISSN: 1433-7851
Language: English
Subjects: Medicinal chemistry; Antibiotic resistance; Drug design
Subject (DDC): 540: Chemistry
615: Pharmacology and therapeutics
Abstract: Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even lastresort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled “Combat drug resistance: no action today means no cure tomorrow” triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.
Fulltext version: Published version
License (according to publishing contract): CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Departement: Life Sciences and Facility Management
Appears in Collections:Publikationen Life Sciences und Facility Management

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