Surface modifications for antimicrobial effects in the healthcare setting : a critical overview

Adlhart, Christian; Verran, Joanna; Azevedo, Nuno F.; Olmez, Hulya; Keinänen-Toivola, Minna M.; Gouveia, Isabel; Melo, Luis F.; Crijns, Francy

doi:10.21256/zhaw-3417

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3417

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Surface modifications for antimicrobial effects in the healthcare setting : a critical overview
Authors:	Adlhart, Christian Verran, Joanna Azevedo, Nuno F. Olmez, Hulya Keinänen-Toivola, Minna M. Gouveia, Isabel Melo, Luis F. Crijns, Francy
DOI:	10.21256/zhaw-3417 10.1016/j.jhin.2018.01.018
Published in:	Journal of Hospital Infection
Issue Date:	2018
Publisher / Ed. Institution:	Elsevier
ISSN:	0195-6701 1532-2939
Language:	English
Subjects:	Healthcare contamination; Antimicrobial coatings; Safe by design
Subject (DDC):	540: Chemistry 620: Engineering
Abstract:	The spread of infections in health care environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (implants, catheters, etc.), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc, or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. The paper addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated to the implementation of such anti-contamination measures. Different chemistry-based approaches are discussed, in particular anti-adhesive surfaces (e.g., superhydrophobic, zwitterions, etc.) contact-killing surfaces (e.g., polymer brushes, phages, etc.) and biocide-releasing surfaces (e.g., triggered release, quorum sensing-based systems, etc.). The paper also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability, etc.) when developing and implementing antimicrobial surfaces.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2763
Fulltext version:	Accepted version
License (according to publishing contract):	CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Adlhart, C., Verran, J., Azevedo, N. F., Olmez, H., Keinänen-Toivola, M. M., Gouveia, I., Melo, L. F., & Crijns, F. (2018). Surface modifications for antimicrobial effects in the healthcare setting : a critical overview. Journal of Hospital Infection. https://doi.org/10.21256/zhaw-3417

Adlhart, C. et al. (2018) ‘Surface modifications for antimicrobial effects in the healthcare setting : a critical overview’, Journal of Hospital Infection [Preprint]. Available at: https://doi.org/10.21256/zhaw-3417.

C. Adlhart et al., “Surface modifications for antimicrobial effects in the healthcare setting : a critical overview,” Journal of Hospital Infection, 2018, doi: 10.21256/zhaw-3417.

ADLHART, Christian, Joanna VERRAN, Nuno F. AZEVEDO, Hulya OLMEZ, Minna M. KEINÄNEN-TOIVOLA, Isabel GOUVEIA, Luis F. MELO und Francy CRIJNS, 2018. Surface modifications for antimicrobial effects in the healthcare setting : a critical overview. Journal of Hospital Infection. 2018. DOI 10.21256/zhaw-3417

Adlhart, Christian, Joanna Verran, Nuno F. Azevedo, Hulya Olmez, Minna M. Keinänen-Toivola, Isabel Gouveia, Luis F. Melo, and Francy Crijns. 2018. “Surface Modifications for Antimicrobial Effects in the Healthcare Setting : A Critical Overview.” Journal of Hospital Infection. https://doi.org/10.21256/zhaw-3417.

Adlhart, Christian, et al. “Surface Modifications for Antimicrobial Effects in the Healthcare Setting : A Critical Overview.” Journal of Hospital Infection, 2018, https://doi.org/10.21256/zhaw-3417.