Titel: Surface modifications for antimicrobial effects in the healthcare setting : a critical overview
Autoren: Adlhart, Christian
Verran, Joanna
Azevedo, Nuno F.
Olmez, Hulya
Keinänen-Toivola, Minna M.
Gouveia, Isabel
Melo, Luis F.
Crijns, Francy
Erschienen in: Journal of Hospital Infection
Verlag / Hrsg. Institution: Elsevier
Erscheinungsdatum: 2018
Sprache: Englisch / English
Schlagwörter: Healthcare contamination; Antimicrobial coatings; Safe by design
Fachgebiet (DDC): 540: Chemie
620: Ingenieurwesen
Zusammenfassung: The spread of infections in health care environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (implants, catheters, etc.), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc, or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. The paper addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated to the implementation of such anti-contamination measures. Different chemistry-based approaches are discussed, in particular anti-adhesive surfaces (e.g., superhydrophobic, zwitterions, etc.) contact-killing surfaces (e.g., polymer brushes, phages, etc.) and biocide-releasing surfaces (e.g., triggered release, quorum sensing-based systems, etc.). The paper also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability, etc.) when developing and implementing antimicrobial surfaces.
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Chemie und Biotechnologie (ICBT)
Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
Art der Begutachtung: Peer review (Publikation)
DOI: 10.1016/j.jhin.2018.01.018
ISSN: 0195-6701
PMID: 29410096
URI: https://digitalcollection.zhaw.ch/handle/11475/2763
Lizenz (gemäss Verlagsvertrag): CC BY-NC-ND 4.0: Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

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