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https://doi.org/10.21256/zhaw-3417| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Surface modifications for antimicrobial effects in the healthcare setting : a critical overview |
| Autor/-in: | Adlhart, Christian Verran, Joanna Azevedo, Nuno F. Olmez, Hulya Keinänen-Toivola, Minna M. Gouveia, Isabel Melo, Luis F. Crijns, Francy |
| DOI: | 10.21256/zhaw-3417 10.1016/j.jhin.2018.01.018 |
| Erschienen in: | Journal of Hospital Infection |
| Erscheinungsdatum: | 2018 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 0195-6701 1532-2939 |
| Sprache: | Englisch |
| Schlagwörter: | Healthcare contamination; Antimicrobial coatings; Safe by design |
| Fachgebiet (DDC): | 540: Chemie 620: Ingenieurwesen |
| Zusammenfassung: | The spread of infections in health care environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (implants, catheters, etc.), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc, or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. The paper addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated to the implementation of such anti-contamination measures. Different chemistry-based approaches are discussed, in particular anti-adhesive surfaces (e.g., superhydrophobic, zwitterions, etc.) contact-killing surfaces (e.g., polymer brushes, phages, etc.) and biocide-releasing surfaces (e.g., triggered release, quorum sensing-based systems, etc.). The paper also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability, etc.) when developing and implementing antimicrobial surfaces. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2763 |
| Volltext Version: | Akzeptierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY-NC-ND 4.0: Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 1-s2.0-S0195670118300628-main.pdf | 468.19 kB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Adlhart, C., Verran, J., Azevedo, N. F., Olmez, H., Keinänen-Toivola, M. M., Gouveia, I., Melo, L. F., & Crijns, F. (2018). Surface modifications for antimicrobial effects in the healthcare setting : a critical overview. Journal of Hospital Infection. https://doi.org/10.21256/zhaw-3417
Adlhart, C. et al. (2018) ‘Surface modifications for antimicrobial effects in the healthcare setting : a critical overview’, Journal of Hospital Infection [Preprint]. Available at: https://doi.org/10.21256/zhaw-3417.
C. Adlhart et al., “Surface modifications for antimicrobial effects in the healthcare setting : a critical overview,” Journal of Hospital Infection, 2018, doi: 10.21256/zhaw-3417.
ADLHART, Christian, Joanna VERRAN, Nuno F. AZEVEDO, Hulya OLMEZ, Minna M. KEINÄNEN-TOIVOLA, Isabel GOUVEIA, Luis F. MELO und Francy CRIJNS, 2018. Surface modifications for antimicrobial effects in the healthcare setting : a critical overview. Journal of Hospital Infection. 2018. DOI 10.21256/zhaw-3417
Adlhart, Christian, Joanna Verran, Nuno F. Azevedo, Hulya Olmez, Minna M. Keinänen-Toivola, Isabel Gouveia, Luis F. Melo, and Francy Crijns. 2018. “Surface Modifications for Antimicrobial Effects in the Healthcare Setting : A Critical Overview.” Journal of Hospital Infection. https://doi.org/10.21256/zhaw-3417.
Adlhart, Christian, et al. “Surface Modifications for Antimicrobial Effects in the Healthcare Setting : A Critical Overview.” Journal of Hospital Infection, 2018, https://doi.org/10.21256/zhaw-3417.
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