Thermal cleavage of the Fmoc protection group

Höck, Stefan; Marti, Roger; Riedl, Rainer; Simeunovic, Marina

doi:10.2533/chimia.2010.200

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Thermal cleavage of the Fmoc protection group
Authors:	Höck, Stefan Marti, Roger Riedl, Rainer Simeunovic, Marina
DOI:	10.2533/chimia.2010.200
Published in:	Chimia
Volume(Issue):	64
Issue:	3
Page(s):	200
Pages to:	202
Issue Date:	Mar-2010
Publisher / Ed. Institution:	Schweizerische Chemische Gesellschaft
ISSN:	0009-4293
Language:	English
Subjects:	Peptide synthesis; Dibenzofulvene; High-temperature NMR; Fmoc protection group
Subject (DDC):	540: Chemistry
Abstract:	The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2759
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Höck, S., Marti, R., Riedl, R., & Simeunovic, M. (2010). Thermal cleavage of the Fmoc protection group. Chimia, 64(3), 200–202. https://doi.org/10.2533/chimia.2010.200

Höck, S. et al. (2010) ‘Thermal cleavage of the Fmoc protection group’, Chimia, 64(3), pp. 200–202. Available at: https://doi.org/10.2533/chimia.2010.200.

S. Höck, R. Marti, R. Riedl, and M. Simeunovic, “Thermal cleavage of the Fmoc protection group,” Chimia, vol. 64, no. 3, pp. 200–202, Mar. 2010, doi: 10.2533/chimia.2010.200.

HÖCK, Stefan, Roger MARTI, Rainer RIEDL und Marina SIMEUNOVIC, 2010. Thermal cleavage of the Fmoc protection group. Chimia. März 2010. Bd. 64, Nr. 3, S. 200–202. DOI 10.2533/chimia.2010.200

Höck, Stefan, Roger Marti, Rainer Riedl, and Marina Simeunovic. 2010. “Thermal Cleavage of the Fmoc Protection Group.” Chimia 64 (3): 200–202. https://doi.org/10.2533/chimia.2010.200.

Höck, Stefan, et al. “Thermal Cleavage of the Fmoc Protection Group.” Chimia, vol. 64, no. 3, Mar. 2010, pp. 200–2, https://doi.org/10.2533/chimia.2010.200.