Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Thermal cleavage of the Fmoc protection group
Authors: Höck, Stefan
Marti, Roger
Riedl, Rainer
Simeunovic, Marina
DOI: 10.2533/chimia.2010.200
Published in: Chimia
Volume(Issue): 64
Issue: 3
Pages: 200
Pages to: 202
Issue Date: Mar-2010
Publisher / Ed. Institution: Schweizerische Chemische Gesellschaft
ISSN: 0009-4293
Language: English
Subjects: Peptide synthesis; Dibenzofulvene; High-temperature NMR; Fmoc protection group
Subject (DDC): 540: Chemistry
Abstract: The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in Collections:Publikationen Life Sciences und Facility Management

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