Title: Thermal cleavage of the Fmoc protection group
Authors : Höck, Stefan
Marti, Roger
Riedl, Rainer
Simeunovic, Marina
Published in : Chimia : international Journal for Chemistry
Volume(Issue) : 64
Issue : 3
Pages : 200
Pages to: 202
Publisher / Ed. Institution : Schweizerische Chemische Gesellschaft
Issue Date: Mar-2010
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Peptide synthesis; Dibenzofulvene; High-temperature NMR; Fmoc protection group
Subject (DDC) : 540: Chemistry
Abstract: The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.2533/chimia.2010.200
ISSN: 0009-4293
URI: https://digitalcollection.zhaw.ch/handle/11475/2759
Appears in Collections:Publikationen Life Sciences und Facility Management

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