| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Transforming eukaryotic cell culture with macromolecular crowding |
| Authors: | Raghunath, Michael Zeugolis, Dimitrios I. |
| et. al: | No |
| DOI: | 10.1016/j.tibs.2021.04.006 |
| Published in: | Trends in Biochemical Sciences |
| Volume(Issue): | 46 |
| Issue: | 10 |
| Page(s): | 805 |
| Pages to: | 811 |
| Issue Date: | 2021 |
| Publisher / Ed. Institution: | Elsevier |
| ISSN: | 0968-0004 1362-4326 |
| Language: | English |
| Subjects: | Cell culture; Drug discovery; Excluded volume effect; Extracellular matrix; Macromolecular crowding; Regenerative medicine; Macromolecular substance; Eukaryotic Cell; Extracellular Matrix |
| Subject (DDC): | 610.28: Biomedicine, biomedical engineering |
| Abstract: | In multicellular organisms, the intracellular and extracellular spaces are considerably packed with a diverse range of macromolecular species. Yet, standard eukaryotic cell culture is performed in dilute, and deprived of macromolecules culture media, that barely imitate the density and complex macromolecular composition of tissues. Essentially, we drown cells in a sea of media and then expect them to perform physiologically. Herein, we argue the use of macromolecular crowding (MMC) in eukaryotic cell culture for regenerative medicine and drug discovery purposes. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/27135 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Raghunath, M., & Zeugolis, D. I. (2021). Transforming eukaryotic cell culture with macromolecular crowding. Trends in Biochemical Sciences, 46(10), 805–811. https://doi.org/10.1016/j.tibs.2021.04.006
Raghunath, M. and Zeugolis, D.I. (2021) ‘Transforming eukaryotic cell culture with macromolecular crowding’, Trends in Biochemical Sciences, 46(10), pp. 805–811. Available at: https://doi.org/10.1016/j.tibs.2021.04.006.
M. Raghunath and D. I. Zeugolis, “Transforming eukaryotic cell culture with macromolecular crowding,” Trends in Biochemical Sciences, vol. 46, no. 10, pp. 805–811, 2021, doi: 10.1016/j.tibs.2021.04.006.
RAGHUNATH, Michael und Dimitrios I. ZEUGOLIS, 2021. Transforming eukaryotic cell culture with macromolecular crowding. Trends in Biochemical Sciences. 2021. Bd. 46, Nr. 10, S. 805–811. DOI 10.1016/j.tibs.2021.04.006
Raghunath, Michael, and Dimitrios I. Zeugolis. 2021. “Transforming Eukaryotic Cell Culture with Macromolecular Crowding.” Trends in Biochemical Sciences 46 (10): 805–11. https://doi.org/10.1016/j.tibs.2021.04.006.
Raghunath, Michael, and Dimitrios I. Zeugolis. “Transforming Eukaryotic Cell Culture with Macromolecular Crowding.” Trends in Biochemical Sciences, vol. 46, no. 10, 2021, pp. 805–11, https://doi.org/10.1016/j.tibs.2021.04.006.
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