| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Disposable bioreactors for plant liquid cultures at litre-scale |
| Authors: | Eibl-Schindler, Regine Werner, Sören Eibl, Dieter |
| DOI: | 10.1002/elsc.200800102 |
| Published in: | Engineering in Life Sciences |
| Volume(Issue): | 9 |
| Issue: | 3 |
| Page(s): | 156 |
| Pages to: | 164 |
| Issue Date: | Jun-2009 |
| Publisher / Ed. Institution: | Wiley |
| Publisher / Ed. Institution: | Weinheim |
| ISSN: | 1618-0240 1618-2863 |
| Language: | English |
| Subjects: | bioreactor |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | Driven by the demands of the market and the manufacturing industry, disposable bioreactors have gained in importance in cell culture-based processes during the last 10 years. Today they are widely accepted in R&D and also in manufacturing where process simplicity, safety and flexibility have top priority. Although disposable bioreactors are mainly used for cell expansions, glycoprotein secretions and virus generations realised with mammalian and insect cell lines, there are several reports delineating their suitability for the cultivation of plant cell and tissue cultures. This review describes the current disposable bioreactor types suitable for growing plant cell suspensions and organ cultures (hairy roots, meristematic clusters, somatic embryos) at Litre-scale. Based on a definition of the term “disposable bioreactor”, a categorisation of the prevalent types for plant liquid cultures is presented. We describe the bioreactor regimes, working principles and bioengineering parameters of mechanically and pneumatically agitated bag bioreactors, which have advantages of process scalability and efficiency. Furthermore, results from the literature and data from our own research (obtained during production of undifferentiated bioactive cells, expressions of secondary metabolites and glycoproteins, and micropropagations of plant tissues) are discussed. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2655 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Eibl-Schindler, R., Werner, S., & Eibl, D. (2009). Disposable bioreactors for plant liquid cultures at litre-scale. Engineering in Life Sciences, 9(3), 156–164. https://doi.org/10.1002/elsc.200800102
Eibl-Schindler, R., Werner, S. and Eibl, D. (2009) ‘Disposable bioreactors for plant liquid cultures at litre-scale’, Engineering in Life Sciences, 9(3), pp. 156–164. Available at: https://doi.org/10.1002/elsc.200800102.
R. Eibl-Schindler, S. Werner, and D. Eibl, “Disposable bioreactors for plant liquid cultures at litre-scale,” Engineering in Life Sciences, vol. 9, no. 3, pp. 156–164, Jun. 2009, doi: 10.1002/elsc.200800102.
EIBL-SCHINDLER, Regine, Sören WERNER und Dieter EIBL, 2009. Disposable bioreactors for plant liquid cultures at litre-scale. Engineering in Life Sciences. Juni 2009. Bd. 9, Nr. 3, S. 156–164. DOI 10.1002/elsc.200800102
Eibl-Schindler, Regine, Sören Werner, and Dieter Eibl. 2009. “Disposable Bioreactors for Plant Liquid Cultures at Litre-Scale.” Engineering in Life Sciences 9 (3): 156–64. https://doi.org/10.1002/elsc.200800102.
Eibl-Schindler, Regine, et al. “Disposable Bioreactors for Plant Liquid Cultures at Litre-Scale.” Engineering in Life Sciences, vol. 9, no. 3, June 2009, pp. 156–64, https://doi.org/10.1002/elsc.200800102.
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