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|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||High-density EEG power topography and connectivity during confusional arousal|
|Publisher / Ed. Institution:||Elsevier|
|Subjects:||Disorder of arousal; NREM-sleep parasomnia; Brain connectivity; Somnambulism; Night terror; Pavor nocturnus|
|Subject (DDC):||616.8: Neurology, diseases of nervous system|
|Abstract:||Confusional arousal is the milder expression of a family of disorders known as Disorders of Arousal (DOA) from non-REM sleep. These disorders are characterized by recurrent abnormal behaviors that occur in a state of reduced awareness for the external environment. Despite frequent amnesia for the nocturnal events, when actively probed, patients are able to report vivid hallucinatory/dream-like mental imagery. Traditional (low-density) scalp and stereo-electroencephalographic (EEG) recordings previously showed a pathological admixture of slow oscillations typical of NREM sleep and wake-like fast-mixed frequencies during these phenomena. However, our knowledge about the specific neural EEG dynamics over the entire brain is limited. We collected 2 consecutive in-laboratory sleep recordings using high-density (hd)-EEG (256 vertex-referenced geodesic system) coupled with standard video-polysomnography (v-PSG) from a 12-year-old drug-naïve and otherwise healthy child with a long-lasting history of sleepwalking. Source power topography and functional connectivity were computed during 20 selected confusional arousal episodes (from -6 to +18 sec after motor onset), and during baseline slow wave sleep preceding each episode (from - 3 to -2 min before onset). We found a widespread increase in slow wave activity (SWA) theta, alpha, beta, gamma power, associated with a parallel decrease in the sigma range during behavioral episodes compared to baseline sleep. Bilateral Broadman area 7 and right Broadman areas 39 and 40 were relatively spared by the massive increase in SWA power. Functional SWA connectivity analysis revealed a drastic increase in the number and complexity of connections from baseline sleep to full-blown episodes, that mainly involved an increased out-flow from bilateral fronto-medial prefrontal cortex and left temporal lobe to other cortical regions. These effects could be appreciated in the 6 sec window preceding behavioral onset. Overall, our results support the idea that DOA are the expression of peculiar brain states, compatible with a partial re-emergence of consciousness.|
|Fulltext version:||Published version|
|License (according to publishing contract):||CC BY 4.0: Attribution 4.0 International|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Computational Life Sciences (ICLS)|
|Published as part of the ZHAW project:||Data mining in neurological medicine|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
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|2022_Castelnovo-etal_High-density-EEG-topography-connectivity-confusional-arousal.pdf||2.25 MB||Adobe PDF|
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Castelnovo, A., Amacker, J., Maiolo, M., Amato, N., Pereno, M., Riccardi, S., Danani, A., Ulzega, S., & Manconi, M. (2022). High-density EEG power topography and connectivity during confusional arousal. Cortex, 155, 62–74. https://doi.org/10.1016/j.cortex.2022.05.021
Castelnovo, A. et al. (2022) ‘High-density EEG power topography and connectivity during confusional arousal’, Cortex, (155), pp. 62–74. Available at: https://doi.org/10.1016/j.cortex.2022.05.021.
A. Castelnovo et al., “High-density EEG power topography and connectivity during confusional arousal,” Cortex, no. 155, pp. 62–74, Jul. 2022, doi: 10.1016/j.cortex.2022.05.021.
Castelnovo, Anna, et al. “High-Density EEG Power Topography and Connectivity during Confusional Arousal.” Cortex, no. 155, July 2022, pp. 62–74, https://doi.org/10.1016/j.cortex.2022.05.021.
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