Upper limb recovery in spinal cord injury : involvement of central and peripheral motor pathways

Petersen, Jens A.; Spiess, Martina; Curt, Armin; Weidner, Norbert; Rupp, Rüdiger; Abel, Rainer; Schubert, Martin

doi:10.1177/1545968316688796

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Upper limb recovery in spinal cord injury : involvement of central and peripheral motor pathways
Authors:	Petersen, Jens A. Spiess, Martina Curt, Armin Weidner, Norbert Rupp, Rüdiger Abel, Rainer Schubert, Martin
et. al:	No
DOI:	10.1177/1545968316688796
Published in:	Neurorehabilitation and Neural Repair
Volume(Issue):	31
Issue:	5
Page(s):	432
Pages to:	441
Issue Date:	May-2017
Publisher / Ed. Institution:	Sage
ISSN:	1545-9683 1552-6844
Language:	English
Subjects:	Clinical neurophysiology; Mechanism; Rehabilitation; Spinal cord injury; Action potential; Adult; Aged; Disability evaluation; Electromyography; Europe; Evoked potential, Motor; Follow-Up Study; Humans; Neural conduction; Neurologic examination; Peripheral nerve; Recovery of function; Retrospective study; Statistics as topic; Upper extremity; Young adult
Subject (DDC):	617: Surgery
Abstract:	Background and Objective: The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. Methods: Compound motor action potentials (CMAPs), motor-evoked potentials (MEPs), and F-waves were recorded from the abductor digiti minimi and CMAP and F-waves from abductor hallucis muscles in 305 patients at about 15 days, 1 month, 3 months, 6 months, and 12 months following an acute traumatic SCI. Results: The MEP amplitudes and F-wave persistences were lower with more severe sensorimotor impairment. They steadily increased in most subgroups within 6 months after SCI. The amplitude of the CMAPs was low for the first 3 months in the most severely affected participants. This was also found for CMAPs from tibial nerve originating well below the cervical lesion level. Improvement in neurophysiological parameters correlated with improved upper extremity motor scores. Conclusion: The results point to a systematic interrelation of corticospinal transmission, spinal motoneuron excitability, and its axon function, respectively. Electrophysiological correlates of neural excitability show distinct spatial and temporal interrelations within central and peripheral motor pathways following acute cervical SCI. A strong secondary deterioration within the peripheral motor system with incomplete or no recovery depends on anatomical distance caudal to lesion and on lesion severity. Electrophysiological assessments may increase the sensitivity of interventional studies in addition to clinical measures.
URI:	https://digitalcollection.zhaw.ch/handle/11475/25579
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Occupational Therapy (IER)
Appears in collections:	Publikationen Gesundheit

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Petersen, J. A., Spiess, M., Curt, A., Weidner, N., Rupp, R., Abel, R., & Schubert, M. (2017). Upper limb recovery in spinal cord injury : involvement of central and peripheral motor pathways. Neurorehabilitation and Neural Repair, 31(5), 432–441. https://doi.org/10.1177/1545968316688796

Petersen, J.A. et al. (2017) ‘Upper limb recovery in spinal cord injury : involvement of central and peripheral motor pathways’, Neurorehabilitation and Neural Repair, 31(5), pp. 432–441. Available at: https://doi.org/10.1177/1545968316688796.

J. A. Petersen et al., “Upper limb recovery in spinal cord injury : involvement of central and peripheral motor pathways,” Neurorehabilitation and Neural Repair, vol. 31, no. 5, pp. 432–441, May 2017, doi: 10.1177/1545968316688796.

PETERSEN, Jens A., Martina SPIESS, Armin CURT, Norbert WEIDNER, Rüdiger RUPP, Rainer ABEL und Martin SCHUBERT, 2017. Upper limb recovery in spinal cord injury : involvement of central and peripheral motor pathways. Neurorehabilitation and Neural Repair. Mai 2017. Bd. 31, Nr. 5, S. 432–441. DOI 10.1177/1545968316688796

Petersen, Jens A., Martina Spiess, Armin Curt, Norbert Weidner, Rüdiger Rupp, Rainer Abel, and Martin Schubert. 2017. “Upper Limb Recovery in Spinal Cord Injury : Involvement of Central and Peripheral Motor Pathways.” Neurorehabilitation and Neural Repair 31 (5): 432–41. https://doi.org/10.1177/1545968316688796.

Petersen, Jens A., et al. “Upper Limb Recovery in Spinal Cord Injury : Involvement of Central and Peripheral Motor Pathways.” Neurorehabilitation and Neural Repair, vol. 31, no. 5, May 2017, pp. 432–41, https://doi.org/10.1177/1545968316688796.