| Publication type: | Book part |
| Type of review: | Editorial review |
| Title: | Intensified and continuous mAb production with single-use systems |
| Authors: | Müller, Jan Teale, Misha Steiner, Sandra Junne, Stefan Neubauer, Peter Eibl, Dieter Eibl-Schindler, Regine |
| et. al: | No |
| DOI: | 10.1007/978-3-030-79871-0_13 |
| Published in: | Cell Culture Engineering and Technology |
| Editors of the parent work: | Pörtner, Ralf |
| Page(s): | 401 |
| Pages to: | 429 |
| Issue Date: | 2021 |
| Series: | Cell Engineering |
| Series volume: | 10 |
| Publisher / Ed. Institution: | Springer |
| Publisher / Ed. Institution: | Cham |
| ISBN: | 978-3-030-79870-3 978-3-030-79871-0 |
| Language: | English |
| Subjects: | CHO cell; Concentrated fed-batch; Flow-through mode; High-seed fed-batch; Multi-column-chromatography; N-1 perfusion; Single-use capture and polishing; Single-use formulation; Single-use virus inactivation and removal |
| Subject (DDC): | 610.28: Biomedicine, biomedical engineering |
| Abstract: | Therapeutic monoclonal antibodies (mAbs) are the fastest-growing class of biotherapeutics. They are mainly used to treat cancer, inflammatory, metabolic and autoimmune diseases. Their commercial production processes are mainly based on Chinese hamster ovary (CHO) suspension cells, which are currently cultivated in fed-batch mode at cubic meter scale. The annually growing market for therapeutic mAbs and the pressure on producers to reduce their manufacturing costs have led to the increasing development of intensified and continuous production processes in recent years. Single-use systems are used in both upstream and downstream processing. This book chapter describes the main intensification approaches and operational architectures of continuous processes realized today, based on the developmental status of single-use technologies used for the up- and downstream processing of mAbs. In this context, the terms “process intensification” and “continuous process” are defined, while the preferential application of single-use systems is described using literature, and further by own studies. Based on the findings, the main challenges for the implementation of intensified and continuous mAb production using single-use systems are identified. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/25318 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Müller, J., Teale, M., Steiner, S., Junne, S., Neubauer, P., Eibl, D., & Eibl-Schindler, R. (2021). Intensified and continuous mAb production with single-use systems. In R. Pörtner (Ed.), Cell Culture Engineering and Technology (pp. 401–429). Springer. https://doi.org/10.1007/978-3-030-79871-0_13
Müller, J. et al. (2021) ‘Intensified and continuous mAb production with single-use systems’, in R. Pörtner (ed.) Cell Culture Engineering and Technology. Cham: Springer, pp. 401–429. Available at: https://doi.org/10.1007/978-3-030-79871-0_13.
J. Müller et al., “Intensified and continuous mAb production with single-use systems,” in Cell Culture Engineering and Technology, R. Pörtner, Ed. Cham: Springer, 2021, pp. 401–429. doi: 10.1007/978-3-030-79871-0_13.
MÜLLER, Jan, Misha TEALE, Sandra STEINER, Stefan JUNNE, Peter NEUBAUER, Dieter EIBL und Regine EIBL-SCHINDLER, 2021. Intensified and continuous mAb production with single-use systems. In: Ralf PÖRTNER (Hrsg.), Cell Culture Engineering and Technology. Cham: Springer. S. 401–429. ISBN 978-3-030-79870-3
Müller, Jan, Misha Teale, Sandra Steiner, Stefan Junne, Peter Neubauer, Dieter Eibl, and Regine Eibl-Schindler. 2021. “Intensified and Continuous mAb Production with Single-Use Systems.” In Cell Culture Engineering and Technology, edited by Ralf Pörtner, 401–29. Cham: Springer. https://doi.org/10.1007/978-3-030-79871-0_13.
Müller, Jan, et al. “Intensified and Continuous mAb Production with Single-Use Systems.” Cell Culture Engineering and Technology, edited by Ralf Pörtner, Springer, 2021, pp. 401–29, https://doi.org/10.1007/978-3-030-79871-0_13.
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