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Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
Art der Begutachtung: Peer review (Publikation)
Titel: Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients : results from a prospective cohort study
Autor/-in: Seiler, Annina
Blum, David
Deuel, Jeremy Werner
Hertler, Caroline
Schettle, Markus
Zipser, Carl Moritz
Ernst, Jutta
Schubert, Maria
von Känel, Roland
Boettger, Soenke
et. al: No
DOI: 10.1017/S147895152000139X
10.21256/zhaw-24019
Erschienen in: Palliative & Supportive Care
Band(Heft): 19
Heft: 3
Seite(n): 294
Seiten bis: 303
Erscheinungsdatum: 2021
Verlag / Hrsg. Institution: Cambridge University Press
ISSN: 1478-9515
1478-9523
Sprache: Englisch
Schlagwörter: Cancer patient; Delirium; Morbidity; Mortality; Precipitating factor; Predisposing factor; Aged; Cohort study; Human; Prevalence; Prospective study; Risk factor; Hospital mortality; Neoplasm
Fachgebiet (DDC): 610.73: Pflege
616: Innere Medizin und Krankheiten
Zusammenfassung: Objective: Delirium is a frequent complication in advanced cancer patients, among whom it is frequently underdiagnosed and inadequately treated. To date, evidence on risk factors and the prognostic impact of delirium on outcomes remains sparse in this patient population. Method: In this prospective observational cohort study at a single tertiary-care center, 1,350 cancer patients were enrolled. Simple and multiple logistic regression models were utilized to identify associations between predisposing and precipitating factors and delirium. Cox proportional-hazards models were used to estimate the effect of delirium on death rate. Results: In our patient cohort, the prevalence of delirium was 34.3%. Delirium was associated inter alia with prolonged hospitalization, a doubling of care requirements, increased healthcare costs, increased need for institutionalization (OR 3.22), and increased mortality (OR 8.78). Predisposing factors for delirium were impaired activity (OR 10.82), frailty (OR 4.75); hearing (OR 2.23) and visual impairment (OR 1.89), chronic pneumonitis (OR 2.62), hypertension (OR 1.46), and renal insufficiency (OR 1.82). Precipitating factors were acute renal failure (OR 7.50), pressure sores (OR 3.78), pain (OR 2.86), and cystitis (OR 1.32). On multivariate Cox regression, delirium increased the mortality risk sixfold (HR 5.66). Age ≥ 65 years and comorbidities further doubled the mortality risk of delirious patients (HR 1.77; HR 2.05). Significance of results: Delirium is common in cancer patients and associated with increased morbidity and mortality. Systematically categorizing predisposing and precipitating factors might yield new strategies for preventing and managing delirium in cancer patients.
Weitere Angaben: Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)
URI: https://digitalcollection.zhaw.ch/handle/11475/24019
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): CC BY 4.0: Namensnennung 4.0 International
Departement: Gesundheit
Organisationseinheit: Institut für Pflege (IPF)
Enthalten in den Sammlungen:Publikationen Gesundheit

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