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|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients : results from a prospective cohort study|
Deuel, Jeremy Werner
Zipser, Carl Moritz
von Känel, Roland
|Published in:||Palliative & Supportive Care|
|Publisher / Ed. Institution:||Cambridge University Press|
|Subjects:||Cancer patient; Delirium; Morbidity; Mortality; Precipitating factor; Predisposing factor; Aged; Cohort study; Human; Prevalence; Prospective study; Risk factor; Hospital mortality; Neoplasm|
|Subject (DDC):||610.73: Nursing |
616: Internal medicine and diseases
|Abstract:||Objective: Delirium is a frequent complication in advanced cancer patients, among whom it is frequently underdiagnosed and inadequately treated. To date, evidence on risk factors and the prognostic impact of delirium on outcomes remains sparse in this patient population. Method: In this prospective observational cohort study at a single tertiary-care center, 1,350 cancer patients were enrolled. Simple and multiple logistic regression models were utilized to identify associations between predisposing and precipitating factors and delirium. Cox proportional-hazards models were used to estimate the effect of delirium on death rate. Results: In our patient cohort, the prevalence of delirium was 34.3%. Delirium was associated inter alia with prolonged hospitalization, a doubling of care requirements, increased healthcare costs, increased need for institutionalization (OR 3.22), and increased mortality (OR 8.78). Predisposing factors for delirium were impaired activity (OR 10.82), frailty (OR 4.75); hearing (OR 2.23) and visual impairment (OR 1.89), chronic pneumonitis (OR 2.62), hypertension (OR 1.46), and renal insufficiency (OR 1.82). Precipitating factors were acute renal failure (OR 7.50), pressure sores (OR 3.78), pain (OR 2.86), and cystitis (OR 1.32). On multivariate Cox regression, delirium increased the mortality risk sixfold (HR 5.66). Age ≥ 65 years and comorbidities further doubled the mortality risk of delirious patients (HR 1.77; HR 2.05). Significance of results: Delirium is common in cancer patients and associated with increased morbidity and mortality. Systematically categorizing predisposing and precipitating factors might yield new strategies for preventing and managing delirium in cancer patients.|
|Further description:||Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)|
|Fulltext version:||Published version|
|License (according to publishing contract):||CC BY 4.0: Attribution 4.0 International|
|Departement:||School of Health Sciences|
|Organisational Unit:||Institute of Nursing (IPF)|
|Appears in collections:||Publikationen Gesundheit|
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Seiler, A., Blum, D., Deuel, J. W., Hertler, C., Schettle, M., Zipser, C. M., Ernst, J., Schubert, M., von Känel, R., & Boettger, S. (2021). Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients : results from a prospective cohort study. Palliative & Supportive Care, 19(3), 294–303. https://doi.org/10.1017/S147895152000139X
Seiler, A. et al. (2021) ‘Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients : results from a prospective cohort study’, Palliative & Supportive Care, 19(3), pp. 294–303. Available at: https://doi.org/10.1017/S147895152000139X.
A. Seiler et al., “Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients : results from a prospective cohort study,” Palliative & Supportive Care, vol. 19, no. 3, pp. 294–303, 2021, doi: 10.1017/S147895152000139X.
Seiler, Annina, et al. “Delirium Is Associated with an Increased Morbidity and In-Hospital Mortality in Cancer Patients : Results from a Prospective Cohort Study.” Palliative & Supportive Care, vol. 19, no. 3, 2021, pp. 294–303, https://doi.org/10.1017/S147895152000139X.
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