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|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem|
Mingo Barba, Sergio
Gaipl, Udo S.
|Publisher / Ed. Institution:||MDPI|
|Subjects:||Antigen pattern; Danger signal; Fractionation; Immune response; Immune system in silico; Perceptron; Systems medicine|
|Subject (DDC):||616: Internal medicine and diseases|
|Abstract:||There is some evidence that radiotherapy (RT) can trigger anti-tumor immune responses. In addition, hyperthermia (HT) is known to be a tumor cell radio-sensitizer. How HT could enhance the anti-tumor immune response produced by RT is still an open question. The aim of this study is the evaluation of potential dynamic effects regarding the adaptive immune response induced by different combinations of RT fractions with HT. The adaptive immune system is considered as a trainable unit (perceptron) which compares danger signals released by necrotic or apoptotic cell death with the presence of tumor- and host tissue cell population-specific molecular patterns (antigens). To mimic the changes produced by HT such as cell radio-sensitization or increase of the blood perfusion after hyperthermia, simplistic biophysical models were included. To study the effectiveness of the different RT+HT treatments, the Tumor Control Probability (TCP) was calculated. In the considered scenarios, the major effect of HT is related to the enhancement of the cell radio-sensitivity while perfusion or heat-based effects on the immune system seem to contribute less. Moreover, no tumor vaccination effect has been observed. In the presented scenarios, HT boosts the RT cell killing but it does not fundamentally change the anti-tumor immune response.|
|Fulltext version:||Published version|
|License (according to publishing contract):||CC BY 4.0: Attribution 4.0 International|
|Departement:||School of Engineering|
|Organisational Unit:||Institute of Applied Mathematics and Physics (IAMP)|
|Published as part of the ZHAW project:||Hyperboost|
|Appears in collections:||Publikationen School of Engineering|
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|2021_Scheidegger-etal_HT-RT-in-artificial-immune-tumor-ecosystem.pdf||1.77 MB||Adobe PDF|
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Scheidegger, S., Mingo Barba, S., & Gaipl, U. S. (2021). Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem. Cancers, 13(22), 5764. https://doi.org/10.3390/cancers13225764
Scheidegger, S., Mingo Barba, S. and Gaipl, U.S. (2021) ‘Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem’, Cancers, 13(22), p. 5764. Available at: https://doi.org/10.3390/cancers13225764.
S. Scheidegger, S. Mingo Barba, and U. S. Gaipl, “Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem,” Cancers, vol. 13, no. 22, p. 5764, Nov. 2021, doi: 10.3390/cancers13225764.
Scheidegger, Stephan, et al. “Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune-Tumor-Ecosystem.” Cancers, vol. 13, no. 22, Nov. 2021, p. 5764, https://doi.org/10.3390/cancers13225764.
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