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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem
Authors: Scheidegger, Stephan
Mingo Barba, Sergio
Gaipl, Udo S.
et. al: No
DOI: 10.3390/cancers13225764
Published in: Cancers
Volume(Issue): 13
Issue: 22
Page(s): 5764
Issue Date: 17-Nov-2021
Publisher / Ed. Institution: MDPI
ISSN: 2072-6694
Language: English
Subjects: Antigen pattern; Danger signal; Fractionation; Immune response; Immune system in silico; Perceptron; Systems medicine
Subject (DDC): 616: Internal medicine and diseases
Abstract: There is some evidence that radiotherapy (RT) can trigger anti-tumor immune responses. In addition, hyperthermia (HT) is known to be a tumor cell radio-sensitizer. How HT could enhance the anti-tumor immune response produced by RT is still an open question. The aim of this study is the evaluation of potential dynamic effects regarding the adaptive immune response induced by different combinations of RT fractions with HT. The adaptive immune system is considered as a trainable unit (perceptron) which compares danger signals released by necrotic or apoptotic cell death with the presence of tumor- and host tissue cell population-specific molecular patterns (antigens). To mimic the changes produced by HT such as cell radio-sensitization or increase of the blood perfusion after hyperthermia, simplistic biophysical models were included. To study the effectiveness of the different RT+HT treatments, the Tumor Control Probability (TCP) was calculated. In the considered scenarios, the major effect of HT is related to the enhancement of the cell radio-sensitivity while perfusion or heat-based effects on the immune system seem to contribute less. Moreover, no tumor vaccination effect has been observed. In the presented scenarios, HT boosts the RT cell killing but it does not fundamentally change the anti-tumor immune response.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: School of Engineering
Organisational Unit: Institute of Applied Mathematics and Physics (IAMP)
Published as part of the ZHAW project: Hyperboost
Appears in collections:Publikationen School of Engineering

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