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Title: Effects of dietary exposure to zearalenone (ZEN) on carp (Cyprinus carpio L.)
Authors : Pietsch-Schmied, Constanze
Kersten, Susanne
Valenta, Hana
Dänicke, Sven
Schulz, Carsten
Burkhardt-Holm, Patricia
Junge, Ranka
Published in : Toxins
Volume(Issue) : 7
Issue : 9
Pages : 3465
Pages to: 3480
Publisher / Ed. Institution : MDPI AG
Issue Date: 2015
License (according to publishing contract) : CC BY 4.0: Namensnennung 4.0 International
Type of review: Not specified
Language : English
Subjects : Blood cell populations; Aquaculture; Feed quality; Genotoxicity
Subject (DDC) : 572: Biochemistry
Abstract: The mycotoxin zearalenone (ZEN) is frequently contaminating animal feeds including feed used in aquaculture. In the present study, the effects of dietary exposure to ZEN on carp (Cyprinus carpio L.) were investigated. ZEN at three different concentrations (low dose: 332 mg kg-1, medium dose: 621 mg kg-1 and high dose: 797 mg kg-1 final feed, respectively) was administered to juvenile carp for four weeks. Additional groups received the mycotoxin for the same time period but were fed with the uncontaminated diet for two more weeks to examine the reversibility of the ZEN effects. No effects on growth were observed during the feeding trial, but effects on haematological parameters occurred. In addition, an influence on white blood cell counts was noted whereby granulocytes and monocytes were affected in fish treated with the medium and high dose ZEN diet. In muscle samples, marginal ZEN and α-zearalenol (a-ZEL) concentrations were detected. Furthermore, the genotoxic potential of ZEN was confirmed by analysing formation of micronuclei in erythrocytes. In contrast to previous reports on other fish species estrogenic effects measured as vitellogenin concentrations in serum samples were not increased by dietary exposure to ZEN. This is probably due to the fact that ZEN is rapidly metabolized in carp.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Natural Resource Sciences (IUNR)
Publication type: Article in scientific Journal
DOI : 10.3390/toxins7093465
ISSN: 2072-6651
Appears in Collections:Publikationen Life Sciences und Facility Management

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