Title: A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps
Authors : Dittler, Ina
Kaiser, Stephan
Blaschczok, Katharina
Löffelholz, Christian
Bösch, Pascal
Dornfeld, Wolfgang
Schöb, Reto
Rojahn, Jürgen
Kraume, Matthias
Eibl, Dieter
Published in : Engineering in Life Sciences
Volume(Issue) : 14
Issue : 3
Pages : 311
Pages to: 317
Publisher / Ed. Institution : Wiley -VCH
Publisher / Ed. Institution: Weinheim
Issue Date: May-2014
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subject (DDC) : 620: Engineering
Abstract: The suitability of oil-water emulsions to predict shear forces in stirred bioreactors under cost-effective and time-saving conditions has been demonstrated several times, but no application to pumps has been described so far. In this report, the drop sizes in a model oil-water system were determined for the Levitronix PuraLev® MU series (PuraLev® 200MU and PuraLev® 600MU), a peristaltic pump (Masterflex® I/P Easy Load), and a 4-piston diaphragm pump (Quattroflow 1200-SU) using inline endoscopy. It was determined that the Sauter mean diameter could be used as a comparison criterion to estimate mechanical stress in pumps. The investigation showed that PuraLev® MU pumps are characterized by up to 59 % larger Sauter mean diameters than their counterparts at comparable operational conditions. This indicates lower hydrodynamic stress in the PuraLev® MU pumps. Using computational fluid dynamics (CFD), a well-streamlined fluid flow and low turbulent energy dissipation rates (TEDR) were found in the PuraLev® MU pumps, which correlated well with experimental results. A calculation model was used to predict the Sauter mean diameter by combining both experimental and CFD data. Good agreement with deviations below 13 % was determined between model predictions and experimental data.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1002/elsc.201300068
ISSN: 1618-2863
URI: https://digitalcollection.zhaw.ch/handle/11475/2344
Appears in Collections:Publikationen Life Sciences und Facility Management

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