Serum testosterone levels and symptom-based depression subtypes in men

Rodgers, Stephanie; Grosse Holtforth, Martin; Hengartner, Michael Pascal; Müller, Mario; Aleksandrowicz, Aleksandra; Rössler, Wulf; Ajdacic-Gross, Vladeta

doi:10.21256/zhaw-1588

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1588

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Serum testosterone levels and symptom-based depression subtypes in men
Authors:	Rodgers, Stephanie Grosse Holtforth, Martin Hengartner, Michael Pascal Müller, Mario Aleksandrowicz, Aleksandra Rössler, Wulf Ajdacic-Gross, Vladeta
DOI:	10.21256/zhaw-1588 10.3389/fpsyt.2015.00061
Published in:	Frontiers in Psychiatry
Volume(Issue):	6
Issue:	61
Issue Date:	4-May-2015
Publisher / Ed. Institution:	Frontiers Research Foundation
ISSN:	1664-0640
Language:	English
Subjects:	Testosterone; Depression; Subtypes; Epidemiology; Cross-sectional study
Subject (DDC):	610: Medicine and health 616.8: Neurology, diseases of nervous system
Abstract:	The main objective of this preliminary study was to further clarify the association between testosterone (T) levels and depression by investigating symptom-based depression subtypes in a sample of 64 men. The data were taken from the ZInEP epidemiology survey. Gonadal hormones of a melancholic (n = 25) and an atypical (n = 14) depression subtype, derived from latent class analysis, were compared with those of healthy controls (n = 18). Serum T was assayed using an enzyme-linked immunosorbent assay procedure. Analysis of variance, analysis of covariance, non-parametrical tests, and generalized linear regression models were performed to examine group differences. The atypical depressive subtype showed significantly lower T levels compared with the melancholic depressives. While accumulative evidence indicates that, beyond psychosocial characteristics, the melancholic and atypical depressive subtypes are also distinguishable by biological correlates, the current study expanded this knowledge to include gonadal hormones. Further longitudinal research is warranted to disclose causality by linking the multiple processes in pathogenesis of depression.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2293
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

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Rodgers, S., Grosse Holtforth, M., Hengartner, M. P., Müller, M., Aleksandrowicz, A., Rössler, W., & Ajdacic-Gross, V. (2015). Serum testosterone levels and symptom-based depression subtypes in men. Frontiers in Psychiatry, 6(61). https://doi.org/10.21256/zhaw-1588

Rodgers, S. et al. (2015) ‘Serum testosterone levels and symptom-based depression subtypes in men’, Frontiers in Psychiatry, 6(61). Available at: https://doi.org/10.21256/zhaw-1588.

S. Rodgers et al., “Serum testosterone levels and symptom-based depression subtypes in men,” Frontiers in Psychiatry, vol. 6, no. 61, May 2015, doi: 10.21256/zhaw-1588.

RODGERS, Stephanie, Martin GROSSE HOLTFORTH, Michael Pascal HENGARTNER, Mario MÜLLER, Aleksandra ALEKSANDROWICZ, Wulf RÖSSLER und Vladeta AJDACIC-GROSS, 2015. Serum testosterone levels and symptom-based depression subtypes in men. Frontiers in Psychiatry. 4 Mai 2015. Bd. 6, Nr. 61. DOI 10.21256/zhaw-1588

Rodgers, Stephanie, Martin Grosse Holtforth, Michael Pascal Hengartner, Mario Müller, Aleksandra Aleksandrowicz, Wulf Rössler, and Vladeta Ajdacic-Gross. 2015. “Serum Testosterone Levels and Symptom-Based Depression Subtypes in Men.” Frontiers in Psychiatry 6 (61). https://doi.org/10.21256/zhaw-1588.

Rodgers, Stephanie, et al. “Serum Testosterone Levels and Symptom-Based Depression Subtypes in Men.” Frontiers in Psychiatry, vol. 6, no. 61, May 2015, https://doi.org/10.21256/zhaw-1588.