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Title: Serum testosterone levels and symptom-based depression subtypes in men
Authors : Rodgers, Stephanie
Grosse Holtforth, Martin
Hengartner, Michael Pascal
Müller, Mario
Aleksandrowicz, Aleksandra A.
Rössler, Wulf
Ajdacic-Gross, Vladeta
Published in : Frontiers in Psychiatry
Volume(Issue) : 6
Issue : 61
Publisher / Ed. Institution : Frontiers Research Foundation
Issue Date: 4-May-2015
License (according to publishing contract) : CC BY 4.0: Attribution 4.0 International
Type of review: Peer review (Publication)
Language : English
Subjects : Testosterone; Depression; Subtypes; Epidemiology; Cross-sectional study
Subject (DDC) : 610: Medicine and health
616.8: Neurology, diseases of nervous system
Abstract: The main objective of this preliminary study was to further clarify the association between testosterone (T) levels and depression by investigating symptom-based depression subtypes in a sample of 64 men. The data were taken from the ZInEP epidemiology survey. Gonadal hormones of a melancholic (n = 25) and an atypical (n = 14) depression subtype, derived from latent class analysis, were compared with those of healthy controls (n = 18). Serum T was assayed using an enzyme-linked immunosorbent assay procedure. Analysis of variance, analysis of covariance, non-parametrical tests, and generalized linear regression models were performed to examine group differences. The atypical depressive subtype showed significantly lower T levels compared with the melancholic depressives. While accumulative evidence indicates that, beyond psychosocial characteristics, the melancholic and atypical depressive subtypes are also distinguishable by biological correlates, the current study expanded this knowledge to include gonadal hormones. Further longitudinal research is warranted to disclose causality by linking the multiple processes in pathogenesis of depression.
Departement: Applied Psychology
Organisational Unit: Psychological Institute (PI)
Publication type: Article in scientific Journal
DOI : 10.3389/fpsyt.2015.00061
ISSN: 1664-0640
Appears in Collections:Publikationen Angewandte Psychologie

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