Title: Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents
Authors : Eibl-Schindler, Regine
Eibl, Dieter
Published in : Bioreactor Systems for Tissue Engineering
Pages : 183
Pages to: 207
Editors of the parent work: Kasper, Cornelia
van Griensven, Martijn
Pörtner, Ralf
Publisher / Ed. Institution : Springer
Publisher / Ed. Institution: Berlin
Issue Date: 2009
License (according to publishing contract) : Licence according to publishing contract
Series : Advances in Biochemical Engineering/Biotechnology
Series volume: 112
Type of review: Not specified
Language : English
Subjects : Keywords Cell expansion; Disposable bag bioreactor; Functional tissue; Stem cells; Therapeutic agents
Subject (DDC) : 610: Medicine and health
660: Chemical engineering
Abstract: In order to increase process efficiency, many pharmaceutical and biotechnology companies have introduced disposable bag technology over the last 10 years. Because this technology also greatly reduces the risk of cross-contamination, disposable bags are preferred in applications in which an absolute or improved process safety is a necessity, namely the production of functional tissue for implantation (tissue engineering), the production of human cells for the treatment of cancer and immune system diseases (cellular therapy), the production of viruses for gene therapies, the production of therapeutic proteins, and veterinary as well as human vaccines. Bioreactors with a pre-sterile cultivation bag made of plastic material are currently used in both development and manufacturing processes primarily operating with animal and human cells at small- and middle-volume scale. Because of their scalability, hydrodynamic expertise and the convincing results of oxygen transport efficiency studies, wave-mixed bioreactors are the most used, together with stirred bag bioreactors and static bags, which have the longest tradition. Starting with a general overview of disposable bag bioreactors and their main applications, this chapter summarizes the working principles and engineering aspects of bag bioreactors suitable for cell expansion, formation of functional tissue and production of therapeutic agents. Furthermore, results from selected cultivation studies are presented and discussed.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Book Part
DOI : 10.1007/10_2008_23
ISBN: 978-3-540-69356-7
URI: https://digitalcollection.zhaw.ch/handle/11475/2269
Appears in Collections:Publikationen Life Sciences und Facility Management

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