Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-1581| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology |
| Authors: | Eibl-Schindler, Regine Kaiser, Stephan Lombriser, Renate Eibl, Dieter |
| DOI: | 10.21256/zhaw-1581 10.1007/s00253-009-2422-9 |
| Published in: | Applied Microbiology and Biotechnology |
| Volume(Issue): | 86 |
| Issue: | 1 |
| Page(s): | 41 |
| Pages to: | 49 |
| Issue Date: | Mar-2010 |
| Publisher / Ed. Institution: | Springer |
| Publisher / Ed. Institution: | Berlin |
| ISSN: | 0175-7598 1432-0614 |
| Language: | English |
| Subjects: | Biomanufacturing; Bioreactor types; Cell cultures; CFD; Disposable bioreactor; Microorganisms; Mobius CellReady 3 L bioreactor |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | Disposable bioreactors have increasingly been incorporated into preclinical, clinical, and production-scale biotechnological facilities over the last few years. Driven by market needs, and, in particular, by the developers and manufacturers of drugs, vaccines, and further biologicals, there has been a trend toward the use of disposable seed bioreactors as well as production bioreactors. Numerous studies documenting their advantages in use have contributed to further new developments and have resulted in the availability of a multitude of disposable bioreactor types which differ in power input, design, instrumentation, and scale of the cultivation container. In this review, the term “disposable bioreactor” is defined, the benefits and constraints of disposable bioreactors are discussed, and critical phases and milestones in the development of disposable bioreactors are summarized. An overview of the disposable bioreactors that are currently commercially available is provided, and the domination of wave-mixed, orbitally shaken, and, in particular, stirred disposable bioreactors in animal cell-derived productions at cubic meter scale is reported. The growth of this type of reactor system is attributed to the recent availability of stirred disposable benchtop systems such as the Mobius CellReady 3 L Bioreactor. Analysis of the data from computational fluid dynamic simulation studies and first cultivation runs confirms that this novel bioreactor system is a viable alternative to traditional cell culture bioreactors at benchtop scale. |
| Further description: | Erworben im Rahmen der Schweizer Nationallizenz (http://www.nationallizenzen.ch) |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2246 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2010_Eibl_Disposable bioreactors_Appl Microbiol Biotechnol.pdf | 251.32 kB | Adobe PDF |  View/Open |
Show full item record
Eibl-Schindler, R., Kaiser, S., Lombriser, R., & Eibl, D. (2010). Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology. Applied Microbiology and Biotechnology, 86(1), 41–49. https://doi.org/10.21256/zhaw-1581
Eibl-Schindler, R. et al. (2010) ‘Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology’, Applied Microbiology and Biotechnology, 86(1), pp. 41–49. Available at: https://doi.org/10.21256/zhaw-1581.
R. Eibl-Schindler, S. Kaiser, R. Lombriser, and D. Eibl, “Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology,” Applied Microbiology and Biotechnology, vol. 86, no. 1, pp. 41–49, Mar. 2010, doi: 10.21256/zhaw-1581.
EIBL-SCHINDLER, Regine, Stephan KAISER, Renate LOMBRISER und Dieter EIBL, 2010. Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology. Applied Microbiology and Biotechnology. März 2010. Bd. 86, Nr. 1, S. 41–49. DOI 10.21256/zhaw-1581
Eibl-Schindler, Regine, Stephan Kaiser, Renate Lombriser, and Dieter Eibl. 2010. “Disposabe Bioreactors : The Current State-of-the-Art and Recommended Applications in Biotechnology.” Applied Microbiology and Biotechnology 86 (1): 41–49. https://doi.org/10.21256/zhaw-1581.
Eibl-Schindler, Regine, et al. “Disposabe Bioreactors : The Current State-of-the-Art and Recommended Applications in Biotechnology.” Applied Microbiology and Biotechnology, vol. 86, no. 1, Mar. 2010, pp. 41–49, https://doi.org/10.21256/zhaw-1581.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.