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Title: Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology
Authors : Eibl-Schindler, Regine
Kaiser, Stephan
Lombriser, Renate
Eibl, Dieter
Published in : Applied Microbiology and Biotechnology
Volume(Issue) : 86
Issue : 1
Pages : 41
Pages to: 49
Publisher / Ed. Institution : Springer
Publisher / Ed. Institution: Berlin
Issue Date: Mar-2010
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (publication)
Language : English
Subjects : Biomanufacturing; Bioreactor types; Cell cultures; CFD; Disposable bioreactor; Microorganisms; Mobius CellReady 3 L bioreactor
Subject (DDC) : 660: Chemical engineering
Abstract: Disposable bioreactors have increasingly been incorporated into preclinical, clinical, and production-scale biotechnological facilities over the last few years. Driven by market needs, and, in particular, by the developers and manufacturers of drugs, vaccines, and further biologicals, there has been a trend toward the use of disposable seed bioreactors as well as production bioreactors. Numerous studies documenting their advantages in use have contributed to further new developments and have resulted in the availability of a multitude of disposable bioreactor types which differ in power input, design, instrumentation, and scale of the cultivation container. In this review, the term “disposable bioreactor” is defined, the benefits and constraints of disposable bioreactors are discussed, and critical phases and milestones in the development of disposable bioreactors are summarized. An overview of the disposable bioreactors that are currently commercially available is provided, and the domination of wave-mixed, orbitally shaken, and, in particular, stirred disposable bioreactors in animal cell-derived productions at cubic meter scale is reported. The growth of this type of reactor system is attributed to the recent availability of stirred disposable benchtop systems such as the Mobius CellReady 3 L Bioreactor. Analysis of the data from computational fluid dynamic simulation studies and first cultivation runs confirms that this novel bioreactor system is a viable alternative to traditional cell culture bioreactors at benchtop scale.
Further description : Erworben im Rahmen der Schweizer Nationallizenz (
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific journal
DOI : 10.21256/zhaw-1581
ISSN: 0175-7598
Appears in Collections:Publikationen Life Sciences und Facility Management

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