|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Local pharmacological induction of angiogenesis : drugs for cells and cells as drugs|
De Pieri, Andrea
Zeugolis, Dimitrios I.
|Published in:||Advanced Drug Delivery Reviews|
|Publisher / Ed. Institution:||Elsevier|
|Subjects:||Angiogenesis; Cell therapy; Cellular gas; Drug delivery; Endothelial cell; Progenitor cell; Prolyl hydroxylase; Secretome; Small compound; Vascularisation; Animal; Cytokines; Drug delivery system; Human; Intercellular signaling peptides and proteins; Pathologic neovascularization; Cell- and tissue-based therapy|
|Subject (DDC):||610.28: Biomedicine, biomedical engineering|
|Abstract:||The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major strategies are evolving. Firstly, various pharmacological agents (growth factors, interleukins, small molecules, DNA/RNA) are locally applied at the ischemic region. Secondly, preparations of living cells with considerable bandwidth of tissue origin, differentiation state and preconditioning are delivered locally, rarely systemically. Thirdly, based on the notion, that cellular effects can be attributed mostly to factors secreted in situ, the cellular secretome (conditioned media, exosomes) has come into the spotlight. We review these three strategies to achieve (neo)angiogenesis in ischemic tissue with focus on the angiogenic mechanisms they tackle, such as transcription cascades, specific signalling steps and cellular gases. We also include cancer-therapy relevant lymphangiogenesis, and shall seek to explain why there are often conflicting data between in vitro and in vivo. The lion's share of data encompassing all three approaches comes from experimental animal work and we shall highlight common technical obstacles in the delivery of therapeutic molecules, cells, and secretome. This plethora of preclinical data contrasts with a dearth of clinical studies. A lack of adequate delivery vehicles and standardised assessment of clinical outcomes might play a role here, as well as regulatory, IP, and manufacturing constraints of candidate compounds; in addition, completed clinical trials have yet to reveal a successful and efficacious strategy. As the biology of angiogenesis is understood well enough for clinical purposes, it will be a matter of time to achieve success for well-stratified patients, and most probably with a combination of compounds.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
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Gaspar, D., Peixoto, R., De Pieri, A., Striegl, B., Zeugolis, D. I., & Raghunath, M. (2019). Local pharmacological induction of angiogenesis : drugs for cells and cells as drugs. Advanced Drug Delivery Reviews, 146, 126–154. https://doi.org/10.1016/j.addr.2019.06.002
Gaspar, D. et al. (2019) ‘Local pharmacological induction of angiogenesis : drugs for cells and cells as drugs’, Advanced Drug Delivery Reviews, 146, pp. 126–154. Available at: https://doi.org/10.1016/j.addr.2019.06.002.
D. Gaspar, R. Peixoto, A. De Pieri, B. Striegl, D. I. Zeugolis, and M. Raghunath, “Local pharmacological induction of angiogenesis : drugs for cells and cells as drugs,” Advanced Drug Delivery Reviews, vol. 146, pp. 126–154, Jun. 2019, doi: 10.1016/j.addr.2019.06.002.
Gaspar, Diana, et al. “Local Pharmacological Induction of Angiogenesis : Drugs for Cells and Cells as Drugs.” Advanced Drug Delivery Reviews, vol. 146, June 2019, pp. 126–54, https://doi.org/10.1016/j.addr.2019.06.002.
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