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dc.contributor.authorBertlein, Sarah-
dc.contributor.authorHochleitner, Gernot-
dc.contributor.authorSchmitz, Michael-
dc.contributor.authorTessmar, Jörg-
dc.contributor.authorRaghunath, Michael-
dc.contributor.authorDalton, Paul D.-
dc.contributor.authorGroll, Jürgen-
dc.date.accessioned2021-03-26T15:10:58Z-
dc.date.available2021-03-26T15:10:58Z-
dc.date.issued2019-04-11-
dc.identifier.issn2192-2640de_CH
dc.identifier.issn2192-2659de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/22183-
dc.description.abstractMelt electrowriting (MEW) is an emerging additive manufacturing technology that direct-writes low-micron diameter fibers into 3D scaffolds with high porosities. Often, the polymers currently used for MEW are hydrophobic thermoplastics that induce unspecific protein adsorption and subsequent uncontrolled cell adhesion. Here are developed a coating strategy for MEW scaffolds based on six-arm star-shaped NCO-poly(ethylene oxide-stat-propylene oxide) (sP(EO-stat-PO)). This permanently hydrophilizes the PCL through the formation of a hydrogel coating and minimizes unspecific interactions with proteins and cells. It also provides the option of simultaneous covalent attachment of bioactive molecules through reaction with isocyanates before these are hydrolyzed. Furthermore, a photoactivatable chemical functionalization is introduced that is not dependent on the time-limited window of isocyanate chemistry. For this, photo-leucine is covalently immobilized into the sP(EO-stat-PO) layer, resulting in a photoactivatable scaffold that enables the binding of sterically demanding molecules at any timepoint after scaffold preparation and coating and is decoupled from the isocyanate chemistry. A successful biofunctionalization of MEW scaffolds via this strategy is demonstrated with streptavidin and collagen as examples. This hydrogel coating system is a generic one that introduces flexible specific and multiple surface functionalization, potentially for a spectrum of polymers made from different manufacturing processes.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofAdvanced Healthcare Materialsde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectPCLde_CH
dc.subjectBiofunctionalizationde_CH
dc.subjectMelt electrowritingde_CH
dc.subjectScaffoldsde_CH
dc.subjectSurface modificationde_CH
dc.subjectCell adhesionde_CH
dc.subjectCollagende_CH
dc.subjectHumande_CH
dc.subjectHydrogelde_CH
dc.subjectHydrophobic and hydrophilic interactionsde_CH
dc.subjectLeucinede_CH
dc.subjectLysinede_CH
dc.subjectMesenchymal stem cellde_CH
dc.subjectOligopeptidesde_CH
dc.subjectPolyesterde_CH
dc.subjectPolyethylenesde_CH
dc.subjectPolypropylenesde_CH
dc.subjectTissue scaffoldsde_CH
dc.subjectUltraviolet raysde_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.titlePermanent hydrophilization and generic bioactivation of melt electrowritten scaffoldsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/adhm.201801544de_CH
dc.identifier.pmid30892836de_CH
zhaw.funding.euNode_CH
zhaw.issue7de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume8de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Bertlein, S., Hochleitner, G., Schmitz, M., Tessmar, J., Raghunath, M., Dalton, P. D., & Groll, J. (2019). Permanent hydrophilization and generic bioactivation of melt electrowritten scaffolds. Advanced Healthcare Materials, 8(7). https://doi.org/10.1002/adhm.201801544
Bertlein, S. et al. (2019) ‘Permanent hydrophilization and generic bioactivation of melt electrowritten scaffolds’, Advanced Healthcare Materials, 8(7). Available at: https://doi.org/10.1002/adhm.201801544.
S. Bertlein et al., “Permanent hydrophilization and generic bioactivation of melt electrowritten scaffolds,” Advanced Healthcare Materials, vol. 8, no. 7, Apr. 2019, doi: 10.1002/adhm.201801544.
BERTLEIN, Sarah, Gernot HOCHLEITNER, Michael SCHMITZ, Jörg TESSMAR, Michael RAGHUNATH, Paul D. DALTON und Jürgen GROLL, 2019. Permanent hydrophilization and generic bioactivation of melt electrowritten scaffolds. Advanced Healthcare Materials. 11 April 2019. Bd. 8, Nr. 7. DOI 10.1002/adhm.201801544
Bertlein, Sarah, Gernot Hochleitner, Michael Schmitz, Jörg Tessmar, Michael Raghunath, Paul D. Dalton, and Jürgen Groll. 2019. “Permanent Hydrophilization and Generic Bioactivation of Melt Electrowritten Scaffolds.” Advanced Healthcare Materials 8 (7). https://doi.org/10.1002/adhm.201801544.
Bertlein, Sarah, et al. “Permanent Hydrophilization and Generic Bioactivation of Melt Electrowritten Scaffolds.” Advanced Healthcare Materials, vol. 8, no. 7, Apr. 2019, https://doi.org/10.1002/adhm.201801544.


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