Publication type: Book
Type of review: Editorial review
Title: Disposable bioreactors
et. al: No
Editors: Eibl-Schindler, Regine
Eibl, Dieter
DOI: 10.1007/978-3-642-01872-5
Extent: 226
Issue Date: 2010
Edition: 1
Series: Advances in Biochemical Engineering/Biotechnology
Publisher / Ed. Institution: Springer
Publisher / Ed. Institution: Berlin
ISBN: 978-3-642-01871-8
978-3-642-01872-5
978-3-642-26162-6
Other identifiers: 0724-6145
1616-8542
Language: English
Subjects: Biochemistry; Bioreactor; Biotechnology; Downstream Processing; Pharmaceuticals; Therapeutics; Tissue Engineering; Transport
Subject (DDC): 660: Chemical engineering
Abstract: Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.
URI: https://digitalcollection.zhaw.ch/handle/11475/22064
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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