Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus

Khojasteh, Abbas; Sanchez-Munoz, Raul; Moyano, Elisabeth; Bonfill, Mercedes; Cusido, Rosa M.; Eibl, Regine; Palazon, Javier

doi:10.1016/j.plaphy.2019.05.029

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus
Authors:	Khojasteh, Abbas Sanchez-Munoz, Raul Moyano, Elisabeth Bonfill, Mercedes Cusido, Rosa M. Eibl, Regine Palazon, Javier
et. al:	No
DOI:	10.1016/j.plaphy.2019.05.029
Published in:	Plant Physiology and Biochemistry
Volume(Issue):	141
Page(s):	133
Pages to:	141
Issue Date:	2019
Publisher / Ed. Institution:	Elsevier
ISSN:	0981-9428 1873-2690
Language:	English
Subjects:	Plant cell culture; Root-rhizome culture; Ruscus aculeatus; Ruscogenin biosynthesis
Subject (DDC):	660.6: Biotechnology
Abstract:	Ruscus aculeatus is a threatened medicinal plant whose main bioactive components, the ruscogenins, have long been used in the treatment of hemorrhoids and varicose veins, but recently demonstrated activity against some types of cancer. Plant cell biofactories could constitute an alternative to the whole plant as a source of ruscogenins. In this pipeline, despite the in vitro recalcitrance of R. aculeatus, after many attempts we developed friable calli and derived plant cell suspensions, and their ruscogenin production was compared with that of organized in vitro plantlet and root-rhizome cultures. Root-rhizomes showed a higher capacity for biomass and ruscogenin production than the cell suspensions and the yields were greatly improved by elicitation with coronatine. Although ruscogenins accumulate in plants mainly in the root-rhizome, it was demonstrated that the aerial part could play an important role in their biosynthesis, as production was higher in the whole plant than in the root-rhizome cultures.
URI:	https://digitalcollection.zhaw.ch/handle/11475/22008
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Khojasteh, A., Sanchez-Munoz, R., Moyano, E., Bonfill, M., Cusido, R. M., Eibl, R., & Palazon, J. (2019). Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus. Plant Physiology and Biochemistry, 141, 133–141. https://doi.org/10.1016/j.plaphy.2019.05.029

Khojasteh, A. et al. (2019) ‘Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus’, Plant Physiology and Biochemistry, 141, pp. 133–141. Available at: https://doi.org/10.1016/j.plaphy.2019.05.029.

A. Khojasteh et al., “Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus,” Plant Physiology and Biochemistry, vol. 141, pp. 133–141, 2019, doi: 10.1016/j.plaphy.2019.05.029.

KHOJASTEH, Abbas, Raul SANCHEZ-MUNOZ, Elisabeth MOYANO, Mercedes BONFILL, Rosa M. CUSIDO, Regine EIBL und Javier PALAZON, 2019. Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus. Plant Physiology and Biochemistry. 2019. Bd. 141, S. 133–141. DOI 10.1016/j.plaphy.2019.05.029

Khojasteh, Abbas, Raul Sanchez-Munoz, Elisabeth Moyano, Mercedes Bonfill, Rosa M. Cusido, Regine Eibl, and Javier Palazon. 2019. “Biotechnological Production of Ruscogenins in Plant Cell and Organ Cultures of Rescus Aculeatus.” Plant Physiology and Biochemistry 141: 133–41. https://doi.org/10.1016/j.plaphy.2019.05.029.

Khojasteh, Abbas, et al. “Biotechnological Production of Ruscogenins in Plant Cell and Organ Cultures of Rescus Aculeatus.” Plant Physiology and Biochemistry, vol. 141, 2019, pp. 133–41, https://doi.org/10.1016/j.plaphy.2019.05.029.