|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus|
Cusido, Rosa M.
|Published in:||Plant Physiology and Biochemistry|
|Publisher / Ed. Institution:||Elsevier|
|Subjects:||Plant cell culture; Root-rhizome culture; Ruscus aculeatus; Ruscogenin biosynthesis|
|Subject (DDC):||660.6: Biotechnology|
|Abstract:||Ruscus aculeatus is a threatened medicinal plant whose main bioactive components, the ruscogenins, have long been used in the treatment of hemorrhoids and varicose veins, but recently demonstrated activity against some types of cancer. Plant cell biofactories could constitute an alternative to the whole plant as a source of ruscogenins. In this pipeline, despite the in vitro recalcitrance of R. aculeatus, after many attempts we developed friable calli and derived plant cell suspensions, and their ruscogenin production was compared with that of organized in vitro plantlet and root-rhizome cultures. Root-rhizomes showed a higher capacity for biomass and ruscogenin production than the cell suspensions and the yields were greatly improved by elicitation with coronatine. Although ruscogenins accumulate in plants mainly in the root-rhizome, it was demonstrated that the aerial part could play an important role in their biosynthesis, as production was higher in the whole plant than in the root-rhizome cultures.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
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Khojasteh, A., Sanchez-Munoz, R., Moyano, E., Bonfill, M., Cusido, R. M., Eibl, R., & Palazon, J. (2019). Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus. Plant Physiology and Biochemistry, 141, 133–141. https://doi.org/10.1016/j.plaphy.2019.05.029
Khojasteh, A. et al. (2019) ‘Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus’, Plant Physiology and Biochemistry, 141, pp. 133–141. Available at: https://doi.org/10.1016/j.plaphy.2019.05.029.
A. Khojasteh et al., “Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus,” Plant Physiology and Biochemistry, vol. 141, pp. 133–141, 2019, doi: 10.1016/j.plaphy.2019.05.029.
Khojasteh, Abbas, et al. “Biotechnological Production of Ruscogenins in Plant Cell and Organ Cultures of Rescus Aculeatus.” Plant Physiology and Biochemistry, vol. 141, 2019, pp. 133–41, https://doi.org/10.1016/j.plaphy.2019.05.029.
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