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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Powerful plant antioxidants : a new biosustainable approach to the production of rosmarinic acid
Authors: Khojasteh, Abbas
Mirjalili, Mohammad Hossein
Alcalde, Miguel Angel
Cusido, Rosa M.
Eibl, Regine
Palazon, Javier
et. al: No
DOI: 10.3390/antiox9121273
Published in: Antioxidants
Volume(Issue): 9
Issue: 12
Page(s): 1273
Issue Date: 2020
Publisher / Ed. Institution: MDPI
ISSN: 2076-3921
Language: English
Subjects: Cell cultures; Lamiaceae; Oxidative stress; Phenolic compound; Rosmarinic acid; Savory
Subject (DDC): 610.28: Biomedicine, biomedical engineering
Abstract: Modern lifestyle factors, such as physical inactivity, obesity, smoking, and exposure to environmental pollution, induce excessive generation of free radicals and reactive oxygen species (ROS) in the body. These by-products of oxygen metabolism play a key role in the development of various human diseases such as cancer, diabetes, heart failure, brain damage, muscle problems, premature aging, eye injuries, and a weakened immune system. Synthetic and natural antioxidants, which act as free radical scavengers, are widely used in the food and beverage industries. The toxicity and carcinogenic effects of some synthetic antioxidants have generated interest in natural alternatives, especially plant-derived polyphenols (e.g., phenolic acids, flavonoids, stilbenes, tannins, coumarins, lignins, lignans, quinines, curcuminoids, chalcones, and essential oil terpenoids). This review focuses on the well-known phenolic antioxidant rosmarinic acid (RA), an ester of caffeic acid and (R)-(+)-3-(3,4-dihydroxyphenyl) lactic acid, describing its wide distribution in thirty-nine plant families and the potential productivity of plant sources. A botanical and phytochemical description is provided of a new rich source of RA, Satureja khuzistanica Jamzad (Lamiaceae). Recently reported approaches to the biotechnological production of RA are summarized, highlighting the establishment of cell suspension cultures of S. khuzistanica as an RA chemical biofactory.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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